Gene delivery strategies for therapeutic proteins production in plants: Emerging opportunities and challenges

LH Peng, TW Gu, Y Xu, HA Dad, JX Liu, JZ Lian… - Biotechnology …, 2022 - Elsevier
There are sharply rising demands for pharmaceutical proteins, however shortcomings
associated with traditional protein production methods are obvious. Genetic engineering of …

Nanoparticle-mediated delivery towards advancing plant genetic engineering

FJ Cunningham, NS Goh, GS Demirer, JL Matos… - Trends in …, 2018 - cell.com
Genetic engineering of plants has enhanced crop productivity in the face of climate change
and a growing global population by conferring desirable genetic traits to agricultural crops …

Therapeutic recombinant protein production in plants: Challenges and opportunities

MJB Burnett, AC Burnett - Plants, People, Planet, 2020 - Wiley Online Library
Societal Impact Statement Therapeutic protein production in plants is an area of great
potential for increasing and improving the production of proteins for the treatment or …

Gene delivery into plant cells for recombinant protein production

Q Chen, H Lai - BioMed research international, 2015 - Wiley Online Library
Recombinant proteins are primarily produced from cultures of mammalian, insect, and
bacteria cells. In recent years, the development of deconstructed virus‐based vectors has …

A nano-biomimetic transformation system enables in planta expression of a reporter gene in mature plants and seeds

CL Izuegbunam, N Wijewantha, B Wone… - Nanoscale …, 2021 - pubs.rsc.org
Plant genetic engineering will be essential to decipher the genomic basis of complex traits,
optimize crop genomics, and enable plant-based production of recombinant proteins …

Transgenic plants for therapeutic proteins: linking upstream and downstream strategies

CL Cramer, JG Boothe, KK Oishi - Plant biotechnology: new products and …, 2000 - Springer
With the new knowledge generated through the Human Genome Project and related
biomedical research comes a potential revolution in drug development strategies. One of the …

Organelle-targeted gene delivery in plants by nanomaterials

SSY Law, T Miyamoto, K Numata - Chemical Communications, 2023 - pubs.rsc.org
Genetic engineering of plants has revolutionized agriculture and has had a significant
impact on our everyday life. It has allowed for the production of crops with longer shelf lives …

[HTML][HTML] Agroinfiltration as an effective and scalable strategy of gene delivery for production of pharmaceutical proteins

Q Chen, H Lai, J Hurtado, J Stahnke… - … techniques in biology …, 2013 - ncbi.nlm.nih.gov
Current human biologics are most commonly produced by mammalian cell culture-based
fermentation technologies. However, its limited scalability and high cost prevent this platform …

Production of heterologous proteins in plants: strategies for optimal expression

PN Desai, N Shrivastava, H Padh - Biotechnology advances, 2010 - Elsevier
Plants are a promising expression system for the production of heterologous proteins,
especially therapeutic proteins. Currently the majority of therapeutic proteins are produced …

Nanomaterial based gene delivery: a promising method for plant genome engineering

SK Jat, J Bhattacharya, MK Sharma - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Nanomaterials have attracted considerable attention from researchers in recent years due to
their unique architecture and small dimensions. Significant progress has been made in the …