Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2
Gain-of-function mutations in LRRK2, which encodes the leucine-rich repeat kinase 2
(LRRK2), are the most common genetic cause of late-onset Parkinson's disease. LRRK2 is …
(LRRK2), are the most common genetic cause of late-onset Parkinson's disease. LRRK2 is …
Structural basis of human LRRK2 membrane recruitment and activation
Mutations in LRRK2 are the most common genetic cause of late-onset Parkinson's disease
(PD). LRRK2 encodes the leucine-rich repeat kinase 2 (LRRK2), whose kinase activity is …
(PD). LRRK2 encodes the leucine-rich repeat kinase 2 (LRRK2), whose kinase activity is …
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
EG Vides, A Adhikari, CY Chiang, P Lis, E Purlyte… - Elife, 2022 - elifesciences.org
Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease,
and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases …
and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases …
[HTML][HTML] Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2)
protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the …
protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the …
Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
G Ito, K Katsemonova, F Tonelli, P Lis… - Biochemical …, 2016 - portlandpress.com
Autosomal dominant mutations that activate the leucine-rich repeat kinase 2 (LRRK2) cause
inherited Parkinson's disease. Recent work has revealed that LRRK2 directly …
inherited Parkinson's disease. Recent work has revealed that LRRK2 directly …
Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase
Parkinson's disease predisposing LRRK2 kinase phosphorylates a group of Rab GTPase
proteins including Rab29, within the effector‐binding switch II motif. Previous work indicated …
proteins including Rab29, within the effector‐binding switch II motif. Previous work indicated …
[HTML][HTML] Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10
X Wang, E Negrou, MT Maloney, VV Bondar… - Scientific Reports, 2021 - nature.com
Variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased
risk for familial and sporadic Parkinson's disease (PD). Pathogenic variants in LRRK2 …
risk for familial and sporadic Parkinson's disease (PD). Pathogenic variants in LRRK2 …
Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase
Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease.
LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we …
LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we …
LRRK2 activation in idiopathic Parkinson's disease
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson's
disease (PD). However, a potential role of wild-type LRRK2 in idiopathic PD (iPD) remains …
disease (PD). However, a potential role of wild-type LRRK2 in idiopathic PD (iPD) remains …
Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2
SH Schmidt, JH Weng, PC Aoto… - Proceedings of the …, 2021 - National Acad Sciences
To explore how pathogenic mutations of the multidomain leucine-rich repeat kinase 2
(LRRK2) hijack its finely tuned activation process and drive Parkinson's disease (PD), we …
(LRRK2) hijack its finely tuned activation process and drive Parkinson's disease (PD), we …