Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and
Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i …

ABSTRACT G-quadruplexes are higher-order DNA and RNA structures formed from G-rich
sequences that are built around tetrads of hydrogen-bonded guanine bases. Potential …

Abstract G-quadruplexes (G4s) have become one of the most exciting nucleic acid
secondary structures. A noncanonical, four-stranded structure formed in guanine-rich DNA …

Among the many unusual conformations of DNA and RNA, quadruplex structures, based on
the guanine quartet, possess several unique properties. These properties, along with the …

Intramolecular G-quadruplexes formed by a single DNA strand have attracted much interest
due to the possibility that they may form in telomeres, oncogene promoter sequences and …

The G-overhangs of telomeres are thought to adopt particular conformations, such as T-
loops or G-quadruplexes. It has been suggested that G-quadruplex structures could be …

In its simplest form, a DNA G-quadruplex is a four-stranded DNA structure that is composed
of stacked guanine tetrads. G-quadruplex-forming sequences have been identified in …

Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer
therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism …

Structural multitude of nucleic acids serves basis for its multiple merits and applications.
During structural transitions, significant to perform respective cellular functions, these DNA …

Certain G-rich DNA sequences readily form four-stranded structures called G-quadruplexes.
These sequence motifs are located in telomeres as a repeated unit, and elsewhere in the …