Mechanical ventilation generates injurious forces that exacerbate lung injury. These forces
disrupt lung barrier integrity, trigger proinflammatory mediator release, and differentially …

The pro-inflammatory response of alveolar macrophages to injurious physical forces during
mechanical ventilation is regulated by the anti-inflammatory microRNA, miR-146a …

Mechanical ventilation generates biophysical forces, including high transmural pressures,
which exacerbate lung inflammation. This study sought to determine whether microRNAs …

Intercellular transfer of microRNAs can mediate communication between critical effector
cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial …

Acute respiratory distress syndrome (ARDS) is a devastating pulmonary disease with
significant in-hospital mortality and is the leading cause of death in COVID-19 patients …

The molecular mechanisms of acute lung injury are incompletely understood. MicroRNAs
(miRNAs) are crucial biological regulators that act by suppressing their target genes and are …

Acute respiratory distress syndrome (ARDS) has high mortality (~ 40%) and requires the
lifesaving intervention of mechanical ventilation. A variety of systemic inflammatory insults …

Postinfluenza bacterial pneumonia is associated with significant mortality and morbidity.
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression …

Micro-RNA (miR)-155 is a novel gene regulator with important roles in inflammation. Herein,
our study aimed to explore the role of miR-155 in LPS-induced acute lung injury (ALI). ALI in …

The aim of this study was to investigate the changes induced by high tidal volume ventilation
(HVTV) in pulmonary expression of micro-RNAs (miRNAs) and identify potential target …