Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
X Yu, H Liu, KA Hamel, MG Morvan, S Yu, J Leff… - Nature …, 2020 - nature.com
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …
[HTML][HTML] Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury
J Peng, N Gu, L Zhou, UB Eyo, M Murugan… - Nature …, 2016 - nature.com
Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of
neuropathic pain. However, the precise respective function of microglia and peripheral …
neuropathic pain. However, the precise respective function of microglia and peripheral …
Dorsal root ganglia macrophages maintain osteoarthritis pain
R Raoof, CM Gil, FPJG Lafeber… - Journal of …, 2021 - Soc Neuroscience
Pain is the major debilitating symptom of osteoarthritis (OA), which is difficult to treat. In OA
patients joint tissue damage only poorly associates with pain, indicating other mechanisms …
patients joint tissue damage only poorly associates with pain, indicating other mechanisms …
Exercise-induced changes to the macrophage response in the dorsal root ganglia prevent neuropathic pain after spinal cord injury
SJ Chhaya, D Quiros-Molina… - Journal of …, 2019 - liebertpub.com
Spinal cord injury (SCI) induces neuropathic pain that is refractory to treatment. Central and
peripheral immune responses to SCI play critical roles in pain development. Although …
peripheral immune responses to SCI play critical roles in pain development. Although …
Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice
JA Kuhn, ID Vainchtein, J Braz, K Hamel, M Bernstein… - Elife, 2021 - elifesciences.org
Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition
characterized by mechanical hypersensitivity. We previously identified microglial activation …
characterized by mechanical hypersensitivity. We previously identified microglial activation …
[HTML][HTML] Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury
JK Niehaus, B Taylor-Blake, L Loo, JM Simon, MJ Zylka - Neuron, 2021 - cell.com
Peripheral nerve injury induces long-term pro-inflammatory responses in spinal cord glial
cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal …
cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal …
Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling
RM Guimarães, CE Aníbal-Silva, M Davoli-Ferreira… - Elife, 2023 - elifesciences.org
Resident macrophages are distributed across all tissues and are highly heterogeneous due
to adaptation to different tissue-specific environments. The resident macrophages of the …
to adaptation to different tissue-specific environments. The resident macrophages of the …
Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse
F Zhang, KI Vadakkan, SS Kim, LJ Wu… - Molecular …, 2008 - journals.sagepub.com
Neuronal plasticity along the pathway for sensory transmission including the spinal cord and
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …
Microglia and neuropathic pain
K Inoue, M Tsuda - Glia, 2009 - Wiley Online Library
In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain—neuropathic pain—is often a …
tissue‐damaging stimuli. One type of pathological pain—neuropathic pain—is often a …
Sex differences in pain: a tale of two immune cells
JCS Mapplebeck, S Beggs, MW Salter - Pain, 2016 - journals.lww.com
Substantial evidence has implicated microglia in neuropathic pain. After peripheral nerve
injury, microglia in the spinal cord proliferate and increase cell-surface expression of the …
injury, microglia in the spinal cord proliferate and increase cell-surface expression of the …