Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of
neuropathic pain. However, the precise respective function of microglia and peripheral …

Pain is the major debilitating symptom of osteoarthritis (OA), which is difficult to treat. In OA
patients joint tissue damage only poorly associates with pain, indicating other mechanisms …

Spinal cord injury (SCI) induces neuropathic pain that is refractory to treatment. Central and
peripheral immune responses to SCI play critical roles in pain development. Although …

Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition
characterized by mechanical hypersensitivity. We previously identified microglial activation …

Peripheral nerve injury induces long-term pro-inflammatory responses in spinal cord glial
cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal …

Resident macrophages are distributed across all tissues and are highly heterogeneous due
to adaptation to different tissue-specific environments. The resident macrophages of the …

Neuronal plasticity along the pathway for sensory transmission including the spinal cord and
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …

In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain—neuropathic pain—is often a …

Substantial evidence has implicated microglia in neuropathic pain. After peripheral nerve
injury, microglia in the spinal cord proliferate and increase cell-surface expression of the …