This article provides a comprehensive narrative review of the history of antiepileptic drugs
(AEDs) and their development over time. Firstly, it explores the significant role of serendipity …

Despite the development of various new antiepileptic drugs (AEDs) since the early 1990s,
the available evidence indicates that the efficacy and tolerability of drug treatment of …

Despite the current availability in the market of over two dozen antiepileptic drugs (AEDs),
about one third of people with epilepsy fail to achieve complete freedom from seizures with …

Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …

Epilepsy is the most common neurological disorder which significantly affects the quality of
life and poses a health as well as economic burden on society. Epilepsy affects …

Preclinical research has facilitated the discovery of valuable drugs for the symptomatic
treatment of epilepsy. Yet, despite these therapies, seizures are not adequately controlled in …

Significant advances have been made in the treatment of epilepsy over the past decades.
However, despite the development of various novel antiepileptic drugs, about one third of …

The number of available anticonvulsant drugs increased in the period spanning over more
than a century, amounting to the current panoply of nearly two dozen so-called antiepileptic …

Introduction: The history of epilepsy dates back to 2000 bc. Yet, it was not until 1912 that the
activity of the first antiepileptic, phenobarbital was discovered by accident. After this …

Epilepsy affects≤ 1% of the world's population. Antiepileptic drugs (AEDs) are the mainstay
of treatment, although more than a third of patients are not rendered seizure free with …