Purpose This study compared the expression of the Ras homolog gene family member A
(RhoA) and Rho-associated coiled-coil kinase (ROCK) signaling pathway members in knee …

Ras homolog gene family, member A (RhoA) and its downstream effector Rho-associated
protein kinase (ROCK) play important roles in multiple cellular processes, but abnormal …

Objective Comprehensive molecular mechanisms connecting stress sensing to cellular
phenotypic alteration is essential for developinga therapeutic strategy for osteoarthritis (OA) …

Ras homolog gene family member A (RhoA) plays a major role in the Wnt/planar cell polarity
(PCP) pathway, which is significantly activated in patients with rheumatoid arthritis (RA). The …

Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease caused by
dysregulated inflammatory reactions, T lymphocyte invasion into the joints, and articular …

Coordinated proliferation and differentiation of growth plate chondrocytes is required for
normal growth and development of the endochondral skeleton, but little is known about the …

Objective There is increasing evidence that the RhoA signaling pathway may play a critical
role in the inflammatory response. This study was undertaken to examine the effects of RhoA …

Purpose: Osteoarthritis (OA) is a degenerative joint disease characterized largely by the
deterioration and loss of articular cartilage in the synovial joint. There are currently no …

Objective The transcription factor SOX9 directly regulates the expression of the major
proteoglycans and collagens comprising the cartilage extracellular matrix. The DNA binding …

[Frontiers in Bioscience 9, 827-833, January 1, 2004] 827 DOWN-REGULATION OF THE
GTPASE RHOB MIGHT BE INVOLVED IN THE PRE-APOPTO Page 1 [Frontiers in Bioscience …