Regulation of peptidoglycan synthesis by outer-membrane proteins

A Typas, M Banzhaf, BB van Saparoea, J Verheul… - Cell, 2010 - cell.com
Growth of the mesh-like peptidoglycan (PG) sacculus located between the bacterial inner
and outer membranes (OM) is tightly regulated to ensure cellular integrity, maintain cell …

Cross-talk between phospholipid synthesis and peptidoglycan expansion by a cell wall hydrolase

N Som, M Reddy - Proceedings of the National Academy of …, 2023 - National Acad Sciences
The Gram-negative bacterial cell envelope is a complex multilayered structure comprising a
bilayered phospholipid (PL) membrane that surrounds the cytoplasm (inner membrane or …

Regulated proteolysis of a cross-link–specific peptidoglycan hydrolase contributes to bacterial morphogenesis

SK Singh, S Parveen, L SaiSree… - Proceedings of the …, 2015 - National Acad Sciences
Bacterial growth and morphogenesis are intimately coupled to expansion of peptidoglycan
(PG), an extensively cross-linked macromolecule that forms a protective mesh-like sacculus …

Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi‐enzyme complexes in Escherichia coli

M Banzhaf, HCL Yau, J Verheul, A Lodge… - The EMBO …, 2020 - embopress.org
The peptidoglycan (PG) sacculus provides bacteria with the mechanical strength to maintain
cell shape and resist osmotic stress. Enlargement of the mesh‐like sacculus requires the …

Regulation of bacterial cell wall growth

AJF Egan, RM Cleverley, K Peters, RJ Lewis… - The FEBS …, 2017 - Wiley Online Library
During growth and propagation, a bacterial cell enlarges and subsequently divides its
peptidoglycan (PG) sacculus, a continuous mesh‐like layer that encases the cell membrane …

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

AN Gray, AJF Egan, IL Van't Veer, J Verheul, A Colavin… - elife, 2015 - elifesciences.org
To maintain cellular structure and integrity during division, Gram-negative bacteria must
carefully coordinate constriction of a tripartite cell envelope of inner membrane …

Regulation of peptidoglycan synthesis and remodelling

AJF Egan, J Errington, W Vollmer - Nature Reviews Microbiology, 2020 - nature.com
Bacteria surround their cell membrane with a net-like peptidoglycan layer, called sacculus,
to protect the cell from bursting and maintain its cell shape. Sacculus growth during …

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

S Leclercq, A Derouaux, S Olatunji, C Fraipont… - Scientific reports, 2017 - nature.com
Bacteria utilize specialized multi-protein machineries to synthesize the essential
peptidoglycan (PG) cell wall during growth and division. The divisome controls septal PG …

Peptidoglycan remodeling enables Escherichia coli to survive severe outer membrane assembly defect

N Morè, AM Martorana, J Biboy, C Otten, M Winkle… - MBio, 2019 - Am Soc Microbiol
Gram-negative bacteria have a tripartite cell envelope with the cytoplasmic membrane (CM),
a stress-bearing peptidoglycan (PG) layer, and the asymmetric outer membrane (OM) …

From the regulation of peptidoglycan synthesis to bacterial growth and morphology

A Typas, M Banzhaf, CA Gross… - Nature Reviews …, 2012 - nature.com
How bacteria grow and divide while retaining a defined shape is a fundamental question in
microbiology, but technological advances are now driving a new understanding of how the …