Dose-limiting toxicities (DLTs) are severe adverse effects that define the maximum tolerated
dose of a cancer drug. In addition to the specific mechanisms of each drug, common …

Chemotherapy is one of the widely used anticancer treatments that involves the use of
powerful cytotoxic drugs to stop tumor growth by targeting rapidly dividing cells through …

Cancer chemotherapy has evolved from the use of cytotoxic drugs that are accompanied by
highly deleterious and often life-threatening side effects, to the application of hormone …

cbt2/2/Suppl. 1 Page 1 ©2003 Landes Bioscience. Not for distribution. Vikas Malhotra
Michael C. Perry Ellis Fischel Cancer Center; University of Missouri; Columbia, Missouri …

Cytotoxic chemotherapy drugs primarily damage proliferating cells and we now know the
molecular target of most of the drugs in clinical use. Even so, non-specificity of cytotoxic …

Adjuvant treatment of malignant gliomas, the most common types of primary brain tumors,
with intravenous (iv) chemotherapy has not significantly improved survival for patients with …

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Understanding the toxicities associated with cancer chemotherapeutic agents is essential to
pharmacists involved in the clinical management of oncology patients. Anticipation of …

Chemotherapeutic drugs exert their effects by interfering with the processes involved in cell
division. Their therapeutic use stems from their ability to cause a greater proportion of cell kill …

Chemotherapeutic drugs exert their effects by interfering with the processes involved in cell
division. Their therapeutic use stems from their ability to cause a greater proportion of cell kill …