Background Alterations in progranulin (PGRN) expression are associated with multiple
neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's …

Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …

Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …

Neurodegenerative diseases such as Alzheimer's disease have proven resistant to new
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …

Progranulin (PGRN) is a secreted glycoprotein expressed in neurons and glia that is
implicated in neuronal survival on the basis that mutations in the GRN gene causing …

Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

Mutation of human GRN, the gene encoding the secreted glycoprotein progranulin, results in
a form of frontotemporal lobar degeneration that is characterized by the presence of …

Progranulin (PGRN), a widely expressed glycoprotein with pleiotropic function, has been
linked to a host of physiological processes and diverse pathological states. A series of …

Progranulin (PGRN), a multifunctional growth factor expressed in various tissues, is involved
in a diversity of physiologic and pathological processes, including cell proliferation, wound …