Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

Overproduction of reactive oxygen species or increased oxidative stress is considered a
major mechanism involved in the pathogenesis of endothelial dysfunction, the initiation and …

Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone,
inhibits platelet function, prevents adhesion of leukocytes, and reduces proliferation of the …

During the last decade basic and clinical research has highlighted the central role of
reactive oxygen species (ROS) in cardiovascular disease. Enhanced production or …

Endothelial dysfunction is an independent predictor of cardiovascular risk. It is found with
aging, and in many conditions associated with increased cardiovascular risk such as …

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the Western
world. Its incidence has been increasing lately in developing countries. Several lines of …

Growing evidence indicates that chronic and acute overproduction of reactive oxygen
species (ROS) under pathophysiologic conditions is integral in the development of …

Increased oxidative stress impairs endothelial function and is thought to mediate vascular
disease. Several pathological conditions increase the production of reactive oxygen species …

The production of reactive oxygen and nitrogen species has been implicated in
atherosclerosis principally as means of damaging low-density lipoprotein that in turn initiates …

Accumulating evidence suggests that oxidant stress alters many functions of the
endothelium, including modulation of vasomotor tone. Inactivation of nitric oxide (NO·) by …