To date, the underlying mechanisms involved intervertebral disc degeneration (IDD) remain
unclear, which has hindered the development of molecular biological therapy for IDD …

Intervertebral disc degeneration (IVDD) is a prevalent cause of low back pain. IVDD is
characterized by abnormal expression of extracellular matrix components such as collagen …

Intervertebral disk degeneration (IDD) is a common aging disease. Excessive apoptosis of
nucleus pulposus (NP) cells has been widely considered a main contributor to IDD …

Intervertebral disc degeneration (IDD) is a leading contributor to low back pain. The
intervertebral disc (IVD) is composed of three tissue types: the central gelatinous nucleus …

Vitamin D is involved in mineral and bone homeostasis, immune responses, anti-
inflammation, anti-infection, and cancer prevention. Vitamin D receptor (VDR) is a nuclear …

Autophagy is an evolutionarily conserved intracellular recirculation system that delivers
cytoplasmic content to lysosomes for degradation, thereby maintaining metabolism and …

Autophagy is a homeostatic mechanism through which intracellular damaged organelles
and proteins are degraded and recycled in response to increased metabolic demands or …

Accumulating evidence shows that genetic polymorphism of the vitamin D receptor (VDR)
gene is associated with intervertebral disc degeneration (IDD), implying that VDR may be …

Background Intervertebral disc degeneration (DD) is an important cause of low back pain
and its precise aetiology is not fully understood, being attributed to cumulative …

Known to be involved in bone‐cartilage metabolism, Vitamin D (VD) may play a role in
human's disc pathophysiology. Given that postmenopausal women are prone to suffer VD …