Differences in circulating γδ T cells in patients with primary colon cancer and relation with prognostic factors

JC Andreu-Ballester, L Galindo-Regal… - PLoS …, 2020 - journals.plos.org
Downregulation of the T cell system has been proposed as a mechanism to block immunity
in colonic cancer (CC). However, little has been studied about circulating αβ and γδ T cells …

The prognostic role of γδ T cells in colorectal cancer based on nomogram

R Ma, M Gong, T Sun, L Su, K Li - European Journal of Medical Research, 2023 - Springer
Objective The aim of the present study was to explore the prognostic role of γδ T cells in
colorectal cancer, and establish a nomogram for predicting the survival of the patients …

γδ T cells are increased in the peripheral blood of patients with gastric cancer

AJ Lee, SG Kim, HD Chae, GH Lee, IH Shin - Clinica Chimica Acta, 2012 - Elsevier
BACKGROUND: γδ T cells are implicated in immunoregulation. However, little is known
about the characteristics of γδ T cells in gastric cancer. In this study, we assessed the …

Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer

S Meraviglia, E Lo Presti, M Tosolini… - …, 2017 - Taylor & Francis
ABSTRACT γδ T cells usually infiltrate many different types of cancer, but it is unclear
whether they inhibit or promote tumor progression. Moreover, properties of tumor-infiltrating …

[HTML][HTML] Controversial role of γδ T cells in colorectal cancer

X Yu, L Wang, Z Niu, L Zhu - American Journal of Cancer Research, 2024 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most frequent type of cancer, and the second leading
cause of cancer-related deaths worldwide. Current treatments for patients with CRC do not …

[HTML][HTML] Analysis of tumor-infiltrating gamma delta T cells in rectal cancer

L Rong, K Li, R Li, HM Liu, R Sun… - World journal of …, 2016 - ncbi.nlm.nih.gov
AIM: To investigate the regulatory effect of Vδ1 T cells and the antitumor activity of Vδ2 T
cells in rectal cancer. METHODS: Peripheral blood, tumor tissues and para-carcinoma …

Antitumor activity and some immunological properties of γδ T-cells from patients with gastrointestinal carcinomas

M Murayama, Y Tanaka, J Yagi, T Uchiyama… - Anticancer …, 2008 - ar.iiarjournals.org
Objectives: Human γδ T-cells expressing Vγ2Jγ1. 2Vδ2-TCR recognize microbial
pyrophosphomonoesters in an MHC-independent manner and exert cytotoxic activity on a …

The γδ T cells dual function and crosstalk with intestinal flora in treating colorectal cancer is a promising area of study

P Lin, Y Yan, Z Zhang, Q Dong, J Yi, Q Li… - International …, 2023 - Elsevier
The occurrence of colorectal cancer (CRC) is highly prevalent and severely affects human
health, with the third-greatest occurrence and the second-greatest rate of death globally …

γδ T cells in hepatocellular carcinoma patients present cytotoxic activity but are reduced in potency due to IL-2 and IL-21 pathways

H Jiang, Z Yang, Z Song, M Green, H Song… - International …, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary liver carcinoma and has one
of the highest mortality rates of all cancers. The γδ T cells could infiltrate HCC and have …

Immune effects of γδ T cells in colorectal cancer: a review

R Ma, D Yuan, Y Guo, R Yan, K Li - Frontiers in immunology, 2020 - frontiersin.org
Gamma delta (γδ) T cells can effectively recognize and kill colorectal cancer (CRC) cells,
thereby suppressing tumor progression via multiple mechanisms. They also have abilities to …