Risk factor management matters more than pharmaceutical cyclooxygenase‐2 inhibition in the prevention of de novo intracranial aneurysms

S Räisänen, J Huttunen, TJ Huuskonen… - European Journal of …, 2022 - Wiley Online Library
Background and purpose Pathophysiological studies of saccular intracranial aneurysm (sIA)
disease have shown that inflammation plays a crucial role in sIA development …

Use of antihypertensive medication and formation of de novo intracranial aneurysms

S Räisänen, J Huttunen, TJ Huuskonen… - European Journal of …, 2022 - Wiley Online Library
Background and purpose Hypertension is a risk factor for subarachnoid hemorrhage and is
also considered a risk factor for saccular intracranial aneurysm (sIA) formation. However …

Roles of inflammation in the natural history of intracranial saccular aneurysms

J Wang, L Wei, H Lu, Y Zhu - Journal of the Neurological Sciences, 2021 - Elsevier
Aneurysmal subarachnoid hemorrhage is caused by intracranial aneurysm (IA) rupture and
results in high rates of mortality and morbidity. Factors contributing to IA generation, growth …

Pharmaceutical Modulation of Intracranial Aneurysm Development and Rupture

A Crane, RM Shanahan, JS Hudson… - Journal of Clinical …, 2024 - mdpi.com
Management of intracranial aneurysms (IAs) is determined by patient age, risk of rupture,
and comorbid conditions. While endovascular and microsurgical interventions offer solutions …

Molecular basis for intracranial aneurysm formation

M Fukuda, T Aoki - Neurovascular Events After Subarachnoid Hemorrhage …, 2015 - Springer
Intracranial aneurysm (IA) is a socially important disease both because it has a high
prevalence and because of the severity of resultant subarachnoid hemorrhages after IA …

Potential role of aspirin in the prevention of aneurysmal subarachnoid hemorrhage

RM Starke, N Chalouhi, D Ding… - Cerebrovascular Diseases, 2015 - karger.com
Background: Inflammation is a key element behind the pathophysiology of cerebral
aneurysm formation and rupture. Aspirin is a potent inhibitor of cyclooxygenase-2 (COX) …

The role of inflammation and potential pharmacological therapy in intracranial aneurysms

W Gruszka, M Zbroszczyk, J Komenda… - Neurologia i …, 2018 - journals.viamedica.pl
Intracranial aneurysms remain important clinical concern. There is relatively low risk of
rupture of symptomless aneurysms incidentally found in MRA or CTA performed due to other …

[引用][C] Reevaluating the impact of antihypertensive medication on intracranial aneurysm formation: a call for clarification and further study

Z Yin, A Wang, J Zhao - European Journal of Neurology, 2024 - Wiley Online Library
Recently, we read with great interest the article 'Use of antihypertensive medication and
formation of de novo intracranial aneurysms' by Räisänen et al.[1]. The study found that …

Nonsteroidal anti-inflammatory drugs: a potential pharmacological treatment for intracranial aneurysm

CL Fisher, SL Demel - Cerebrovascular diseases extra, 2019 - karger.com
Background: Saccular intracranial aneurysms (IAs) are outpouchings of the vessel wall of
intracranial arteries. Rupture of IAs results in subarachnoid hemorrhage which is associated …

“Sit back, observe, and wait.” Or is there a pharmacologic preventive treatment for cerebral aneurysms?

MM Valença - Neurosurgical review, 2013 - Springer
Intracranial aneurysms (IA) are a relatively frequent vascular abnormality. The prevailing
opinion is that cerebral aneurysmal disease is related to hemodynamic and genetic factors …