Introduction: Statins reduce the risk of cardiovascular morbidity and mortality in patients with
or at risk for cardiovascular disease and their use is expanding, especially in elderly. Statins …

Introduction: Statin monotherapy is generally well tolerated, with a low frequency of adverse
events. The most important adverse effects associated with statins are myopathy and an …

Background: As the clinical complexity of patients at high cardiovascular risk and with
multiple comorbid conditions increases, so does the potential for drug–drug interactions …

The statins are widely used worldwide to reduce risk for cardiovascular events in both the
primary and secondary prevention settings. Although generally quite safe, the statins can be …

Objective To describe the most important potential adverse effects related to statin therapy,
discuss mechanisms of toxicity and drug interactions, and suggest approaches for …

Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The
most important adverse effects associated with statins are myopathy and an asymptomatic …

Randomized controlled trials with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)
reductase inhibitors (statins) have consistently demonstrated significant reductions in …

HMG-CoA reductase inhibitors ('statins') represent the most effective and widely prescribed
drugs currently available for the reduction of low-density lipoprotein cholesterol, a critical …

One in 4 Americans> 40 years of age takes a statin to reduce the risk of myocardial
infarction, ischemic stroke, and other complications of atherosclerotic disease. The most …

Introduction: Lipid-lowering drugs, especially hydroxymethylglutaryl-CoA reductase
inhibitors (statins), are widely used in the treatment and prevention of atherosclerotic …