Aims Although telomere length (TL) and telomere maintenance proteins (shelterins) are
markers of cellular senescence and peripheral blood biomarkers of Alzheimer's disease …

Alzheimer's disease-related atrophy in the posterior cingulate cortex, a key node of the
default mode network, is present in the early stages of disease progression across clinical …

Introduction While telomere shortening, a marker of cellular aging, may impact the
progression of age-related neurodegenerative diseases, its association with cognition is …

Diagnosis of Alzheimer's disease (AD) in its earliest stages becomes increasingly important
as disease modifying agents are being developed. In this area of research, many clinical …

Aims Lewy body diseases (LBD) are characterized by alpha‐synuclein (SYN) pathology, but
comorbid Alzheimer's disease (AD) pathology is common and the relationship between …

Abstract Background Although Alzheimer disease (AD) and primary age‐related tauopathy
(PART) both harbor 3R/4R‐tau immunopositive Alzheimer‐type neurofibrillary degeneration …

Clarifying the mechanisms connecting neurofibrillary tangle (NFT) neurotoxicity to neuronal
dysfunction in humans is likely to be pivotal for developing effective treatments for …

Detecting deviations from healthy brain aging is critical for identifying individuals at greatest
risk for developing dementia. Yet because there is substantial overlap in patterns of …

Normal aging is often difficult to distinguish from the earliest stages of Alzheimer's disease.
Years before clinical memory deficits manifest, amyloid-β deposits in the cortex in many …

Primary age-related tauopathy (PART) is a neurodegenerative entity defined as Alzheimer-
type neurofibrillary degeneration primarily affecting the medial temporal lobe with minimal to …