Alternatively activated macrophages (AAMs) contribute to the resolution of inflammation and
tissue repair. However, molecular pathways that govern their differentiation have remained …

Macrophages display a spectrum of functional activation phenotypes depending on the
composition of the microenvironment they reside in, including type of tissue/organ and …

Lymph-node (LN) stromal cell populations expand during the inflammation that
accompanies T cell activation. Interleukin-17 (IL-17)-producing helper T cells (TH17 cells) …

Splenic red pulp macrophages (RPMs) contribute to erythrocyte homeostasis and are
required for iron recycling. Heme induces the expression of SPIC transcription factor in …

Classical activation of M1 macrophages with lipopolysaccharide (LPS) is associated with a
metabolic switch from oxidative phosphorylation to glycolysis. However, the generalizability …

Group 2 innate lymphoid cells (ILC2s) and regulatory T (Treg) cells are systemically induced
by helminth infection but also sustain metabolic homeostasis in adipose tissue and …

Exposure of human monocytes/macrophages to anti-inflammatory agents, such as IL-10 or
glucocorticoids, can lead to two separate fates: either Fas/CD95-mediated apoptosis or …

Mitochondria are master regulators of metabolism. Mitochondria generate ATP by oxidative
phosphorylation using pyruvate (derived from glucose and glycolysis) and fatty acids (FAs) …

T-cell-based therapies represent a promising strategy for cancer treatment. In this context,
cytokines are discussed as a bona fide instrument for fine-tuning T-cell biology. One …

Interleukin 10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in the control of
immune responses. However, its mechanisms of action remain poorly understood. Here, we …