T cells have the capacity to eradicate diseased cells, but tumours present considerable
challenges that render T cells ineffectual. Cancer cells often make themselves …

Immunotherapies are emerging as highly promising approaches for the treatment of cancer.
In these approaches, a variety of materials are used to boost immunity against malignant …

It is now well established that the immune system can control and eliminate cancer cells.
Adoptive T cell transfer has the potential to overcome the significant limitations associated …

Immunotherapy is receiving much attention as a means of treating cancer, but complete,
durable responses remain rare for most malignancies. The natural immune system seems to …

Recent advances enabling efficient delivery of transgenes to human T cells have created
opportunities to address obstacles that previously hindered the application of T cell therapy …

Genetically engineered T cells are powerful new medicines, offering hope for curative
responses in patients with cancer. Chimeric antigen receptor (CAR) T cells were recently …

The immune system evolved to distinguish non-self from self to protect the organism. As
cancer is derived from our own cells, immune responses to dysregulated cell growth present …

Genetically engineered T cell immunotherapies have provided remarkable clinical success
to treat B cell acute lymphoblastic leukaemia by harnessing a patient's own T cells to kill …

The genetic modification of T lymphocytes is an important approach to investigating normal
T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to …

Tumours use many strategies to evade the host immune response, including
downregulation or weak immunogenicity of target antigens and creation of an immune …