Antiviral drug resistance of human cytomegalovirus

NS Lurain, S Chou - Clinical microbiology reviews, 2010 - Am Soc Microbiol
The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced
knowledge of the virological targets and the mechanisms of antiviral activity. The currently …

Resistance of human cytomegalovirus to antiviral drugs

A Erice - Clinical Microbiology Reviews, 1999 - Am Soc Microbiol
Resistance of cytomegalovirus (CMV) to antiviral agents is a well-recognized phenomenon
that has been observed in the laboratory and in the clinical setting. Infections caused by …

The biology of cytomegalovirus drug resistance

M Hakki, S Chou - Current opinion in infectious diseases, 2011 - journals.lww.com
An increasing volume of information correlating CMV genotypes and drug susceptibility
phenotypes is becoming available. This will improve the interpretation of sequence-based …

A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes

M Chevillotte, J von Einem, BM Meier, FM Lin… - Antiviral research, 2010 - Elsevier
Drug resistant strains of human cytomegalovirus (HCMV) in patients at risk may increasingly
develop into a problem in the clinical setting. Genotypic resistance testing is becoming the …

Antiviral treatment of cytomegalovirus infection and resistant strains

A Schreiber, G Härter, A Schubert… - Expert opinion on …, 2009 - Taylor & Francis
This review discusses the management of resistant cytomegalovirus and prevention
strategies for fatal therapy failures. Five drugs, ganciclovir/valganciclovir, cidofovir, foscarnet …

Antiviral drug resistance in human cytomegalovirus

S Chou - Transplant infectious disease, 1999 - Wiley Online Library
Drug‐resistant cytomegalovirus (CMV) should be considered when viral shedding persists
after several weeks of therapy. The problem is most likely to arise in the setting of a severely …

Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene

S Chou, LC Van Wechel, HM Lichy… - Antimicrobial agents …, 2005 - Am Soc Microbiol
ABSTRACT A new recombinant phenotyping method was developed for the analysis of drug
resistance mutations in human cytomegalovirus (CMV). CMV strain T2211 was derived from …

Antiviral treatment of cytomegalovirus infection

A Ahmed - Infectious Disorders-Drug Targets (Formerly Current …, 2011 - ingentaconnect.com
Cytomegalovirus (CMV) is an opportunistic pathogen associated with significant morbidity
and mortality in immunocompromised hosts. Antiviral agents specifically targeting CMV were …

Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates

GM Scott, A Weinberg, WD Rawlinson… - Antimicrobial agents …, 2007 - Am Soc Microbiol
The emergence of antiviral-resistant cytomegalovirus (CMV) strains is a continuing clinical
problem, with increased numbers of immunocompromised patients given longer-duration …

Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs

F Baldanti, N Lurain, G Gerna - Human immunology, 2004 - Elsevier
The emergence of human cytomegalovirus (HCMV) drug resistant strains is a life-
threatening condition in immunocompromised individuals with active HCMV infection …