Breast cancer is the most common malignant cancer in women worldwide. Cancer
metastasis is the major cause of cancer-related deaths. BCKDK is associated with various …

Background DKK1 has been reported to act as a tumor suppressor in breast cancer.
However, the mechanism of DKK1 inhibits breast cancer migration and invasion was still …

In metastatic breast cancers, the acquisition of metastatic ability, which leads to clinically
incurable disease and poor survival, has been associated with acquisition of epithelial …

Background Aberrant regulation in the invasion of cancer cells is closely associated with
their metastatic potentials. TrkB functions as a receptor tyrosine kinase and is considered to …

Introduction Amplification of the TNK2 gene in primary tumours correlates with poor
prognosis. In accordance, TNK2 overexpression was shown to promote invasion of cancer …

Brain-derived neurotrophic factor (BDNF) has previously been demonstrated to be
associated with several types of cancer. In addition, its receptor, tropomyosin related kinase …

Platelets can promote several stages of the metastatic process and thus contribute to
malignant progression. As an example, platelets promote invasive properties of tumor cells …

TOPK has been suggested to contribute to invasion of lung, prostate, gastric, pancreatic or
breast cancer cells. However, how TOPK mediates TGF-β1/Smad signaling leading to …

Background Chemoresistance is a critical risk problem for breast cancer treatment.
However, mechanisms by which chemoresistance arises remains to be elucidated. The …

Abstract C-terminal binding protein-2 (CtBP2) enhances cancer proliferation and metastasis.
The role and mechanism of CtBP2 in breast cancer remains to be elucidated. Western blot …