To understand the signalling mechanisms involved in the dual stimulatory effects of
endothelin-1 (ET-1) on DNA synthesis and melanization in cultured human melanocytes, we …

We previously reported that activation of mitogen-activated protein kinase (MAPK) is
involved in the mitogenic stimulation of normal human melanocytes (NHMC) by endothelin-1 …

We demonstrate here that human melanocytes could be regulated by endothelin (ET)
derivatives, potent vasoconstrictive peptides synthesized by endothelial cells, to stimulate …

We recently demonstrated that human melanocyte proliferation and differentiation could be
stimulated by endothelin (ET) derivatives via a receptor-mediated signal transduction …

The paracrine linkage of endothelins (ET) between keratinocytes and melanocytes
suggested that ETs are intrinsic mediators for human melanocytes in UVB‐induced …

Abstract Endothelin (ET)-1, alpha-melanocyte stimulating hormone (alpha-melanotropin;
alpha-MSH), and basic fibroblast growth factor (bFGF) are keratinocyte-derived factors that …

Melanocytes in the skin are derived from the embryonic neural crest. Recently, mutations in
endothelin 3 and the endothelin receptor B genes have been shown to result in gross …

Endothelin (Edn) signaling via the G‐coupled, Edn receptor type B (Ednrb) is essential for
the development of melanocytes from the neural crest (NC) and has been associated with …

The human epidermal-melanin unit exists as a complex interplay of cell-cell interactions.
Melanocytes synthesize melanin and transfer it to the surrounding keratinocytes, which, in …

The endothelin receptor B gene (Ednrb) encodes a G-protein-coupled receptor that is
expressed in a variety of cell types and is specifically required for the development of neural …