The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein
B–containing lipoproteins. Local biological responses to these retained lipoproteins …

The pathogenesis for atherosclerosis is still unclear, and several hypotheses have been
articulated to explain the initiating events in atherogenesis. Although these hypotheses are …

Subendothelial retention of apoB-lipoproteins is the key initiating event in atherosclerosis,
provoking a cascade of pathogenic responses. Dissection of the molecular participants …

The perspective of this review is to highlight recent advances in the area of arterial
lipoprotein retention and the physiological significance these processes may have in the …

Many lines of evidence indicate that the key initiating event in early atherosclerosis is the
subendothelial retention of cholesterol‐rich, atherogenic lipoproteins. Once retained, these …

LDL and other cholesterol-rich, apoB-containing lipoproteins, once they become retained
and modified within the arterial wall, cause atherosclerosis. This simple, robust …

Atherosclerosis is distinguished by the accumulation of lipoprotein lipid within the arterial
wall. An ionic interaction of positively charged regions of apolipoprotein (apo) B with matrix …

Dyslipidemia, characterized by a high level of lipids (cholesterol, triglycerides, or both), can
increase the risk of developing and progressing atherosclerosis. As atherosclerosis …

Background: Patients with familial hypercholesterolemia (FH) are characterized by elevated
atherogenic lipoprotein particles, predominantly low-density lipoprotein cholesterol (LDL-C) …

Looking back at animal and clinical studies published since the 1920s, the notion of rapid
regression and stabilization of atherosclerosis in humans has evolved from a fanciful goal to …