[HTML][HTML] Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease

E Sinclair, DK Trivedi, D Sarkar, C Walton-Doyle… - Nature …, 2021 - nature.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is
characterised by degeneration of distinct neuronal populations, including dopaminergic …

Discovery of volatile biomarkers of Parkinson's disease from sebum

DK Trivedi, E Sinclair, Y Xu, D Sarkar… - ACS central …, 2019 - ACS Publications
Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with
significant motor symptoms, for which there is no diagnostic chemical test. We have …

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies

T Hatano, S Saiki, A Okuzumi, RP Mohney… - Journal of Neurology …, 2016 - jnnp.bmj.com
Objective The pathogenesis of Parkinson's disease (PD) involves complex interactions
between environmental and genetic factors. Metabolomics can shed light on alterations in …

Biochemical profiling of the brain and blood metabolome in a mouse model of prodromal Parkinson's disease reveals distinct metabolic profiles

SF Graham, NL Rey, A Yilmaz, P Kumar… - Journal of proteome …, 2018 - ACS Publications
Parkinson's disease is the second most common neurodegenerative disease. In the vast
majority of cases the origin is not genetic and the cause is not well understood, although …

[HTML][HTML] Promising metabolite profiles in the plasma and CSF of early clinical Parkinson's disease

D Stoessel, C Schulte… - Frontiers in aging …, 2018 - frontiersin.org
Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular
pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging …

[HTML][HTML] Comprehensive metabolic profiling of Parkinson's disease by liquid chromatography-mass spectrometry

Y Shao, T Li, Z Liu, X Wang, X Xu, S Li, G Xu… - Molecular …, 2021 - Springer
Background Parkinson's disease (PD) is a prevalent neurological disease in the elderly with
increasing morbidity and mortality. Despite enormous efforts, rapid and accurate diagnosis …

Metabolomic analysis of urine and serum in Parkinson's disease

AW Michell, D Mosedale, DJ Grainger, RA Barker - Metabolomics, 2008 - Springer
Objective To investigate the metabolic profile of serum and urine samples from 23 female
patients with Parkinson's disease (PD) and 23 age and sex-matched controls. Methods We …

[HTML][HTML] Recent advances and perspectives of metabolomics-based investigations in Parkinson's disease

Y Shao, W Le - Molecular neurodegeneration, 2019 - Springer
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the
central nervous system (CNS), which affects mostly older adults. In recent years, the …

[HTML][HTML] Integrated metabolomics and proteomics analysis reveals plasma lipid metabolic disturbance in patients with Parkinson's disease

L Hu, MX Dong, YL Huang, CQ Lu, Q Qian… - Frontiers in Molecular …, 2020 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disease in the elderly with a
pathogenesis that remains unclear. We aimed to explore its pathogenesis through plasma …

Metabolomic biomarkers as strong correlates of Parkinson disease progression

PA LeWitt, J Li, M Lu, L Guo, P Auinger - Neurology, 2017 - AAN Enterprises
Objective: To determine whether a Parkinson disease (PD)-specific biochemical signature
might be found in the total body metabolic milieu or in the CSF compartment, especially …