[HTML][HTML] Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is
characterised by degeneration of distinct neuronal populations, including dopaminergic …
characterised by degeneration of distinct neuronal populations, including dopaminergic …
Discovery of volatile biomarkers of Parkinson's disease from sebum
Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with
significant motor symptoms, for which there is no diagnostic chemical test. We have …
significant motor symptoms, for which there is no diagnostic chemical test. We have …
Identification of novel biomarkers for Parkinson's disease by metabolomic technologies
T Hatano, S Saiki, A Okuzumi, RP Mohney… - Journal of Neurology …, 2016 - jnnp.bmj.com
Objective The pathogenesis of Parkinson's disease (PD) involves complex interactions
between environmental and genetic factors. Metabolomics can shed light on alterations in …
between environmental and genetic factors. Metabolomics can shed light on alterations in …
Biochemical profiling of the brain and blood metabolome in a mouse model of prodromal Parkinson's disease reveals distinct metabolic profiles
Parkinson's disease is the second most common neurodegenerative disease. In the vast
majority of cases the origin is not genetic and the cause is not well understood, although …
majority of cases the origin is not genetic and the cause is not well understood, although …
[HTML][HTML] Promising metabolite profiles in the plasma and CSF of early clinical Parkinson's disease
D Stoessel, C Schulte… - Frontiers in aging …, 2018 - frontiersin.org
Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular
pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging …
pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging …
[HTML][HTML] Comprehensive metabolic profiling of Parkinson's disease by liquid chromatography-mass spectrometry
Background Parkinson's disease (PD) is a prevalent neurological disease in the elderly with
increasing morbidity and mortality. Despite enormous efforts, rapid and accurate diagnosis …
increasing morbidity and mortality. Despite enormous efforts, rapid and accurate diagnosis …
Metabolomic analysis of urine and serum in Parkinson's disease
AW Michell, D Mosedale, DJ Grainger, RA Barker - Metabolomics, 2008 - Springer
Objective To investigate the metabolic profile of serum and urine samples from 23 female
patients with Parkinson's disease (PD) and 23 age and sex-matched controls. Methods We …
patients with Parkinson's disease (PD) and 23 age and sex-matched controls. Methods We …
[HTML][HTML] Recent advances and perspectives of metabolomics-based investigations in Parkinson's disease
Y Shao, W Le - Molecular neurodegeneration, 2019 - Springer
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the
central nervous system (CNS), which affects mostly older adults. In recent years, the …
central nervous system (CNS), which affects mostly older adults. In recent years, the …
[HTML][HTML] Integrated metabolomics and proteomics analysis reveals plasma lipid metabolic disturbance in patients with Parkinson's disease
L Hu, MX Dong, YL Huang, CQ Lu, Q Qian… - Frontiers in Molecular …, 2020 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disease in the elderly with a
pathogenesis that remains unclear. We aimed to explore its pathogenesis through plasma …
pathogenesis that remains unclear. We aimed to explore its pathogenesis through plasma …
Metabolomic biomarkers as strong correlates of Parkinson disease progression
PA LeWitt, J Li, M Lu, L Guo, P Auinger - Neurology, 2017 - AAN Enterprises
Objective: To determine whether a Parkinson disease (PD)-specific biochemical signature
might be found in the total body metabolic milieu or in the CSF compartment, especially …
might be found in the total body metabolic milieu or in the CSF compartment, especially …