Cannabinoid receptors (CB1 and CB2) are promising targets for a better understanding of
neurological diseases. Nevertheless, only a few ligands of CB have reached clinical …

Cannabinoid (CB) receptor agonists show robust antinociceptive effects in various pain
models. However, most of the clinically potent CB1 receptor-active drugs derived from …

The endocannabinoid system exerts an important neuromodulatory role in mammals.
Knockout mice lacking cannabinoid (CB) receptors exhibit significant morbidity. The …

The endocannabinoid (eCB) system has attracted attention for its role in various behavioral
and brain functions, and as a therapeutic target in neuropsychiatric disease states, including …

We have investigated whether a 1: 1 combination of botanical extracts enriched in either Δ9-
tetrahydrocannabinol (Δ9-THC) or cannabidiol (CBD), which are the main constituents of the …

Cannabinoid CB1 receptor (CB1R) signaling has been suggested to play an important role
in the regulation of memory and cognition. In the present study, our aim was to investigate …

Recent studies have demonstrated the pivotal involvement of endocannabinoids in
regulating learning and memory, but the conclusions obtained from different paradigms or …

As of July 2019, 34 states in the US have legalized medical marijuana and an additional 12
have legalized “low THC, high cannabidiol (CBD)” substances (Hanson & Garcia, 2019) …

Terpenes are the most extensive and varied group of naturally occurring compounds mostly
found in plants, including cannabis, and have an array of potential therapeutic benefits for …

Large conductance, Ca2+-activated K+ (BKCa) channels are widely expressed in the central
nervous system, where they regulate action potential duration, firing frequency and …