Abstract Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation
of in vivo cell-cell and cell-extracellular matrix interactions than conventional two …

The human nervous system is a remarkably complex physiological network that is inherently
challenging to study because of obstacles to acquiring primary samples. Animal models …

To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly
hampered by the lack of suitable disease models. Indeed, animal models do not faithfully …

Current therapies for nerve regeneration within injured tissues have had limited success due
to complicated neural anatomy and inhibitory barriers in situ. Recent advancements in 3D …

Neurodegenerative diseases affect millions of individuals in North America and cost the
health-care industry billions of dollars for treatment. Current treatment options for …

Neural regeneration devices interface with the nervous system and can provide flexibility in
material choice, implantation without the need for additional surgeries, and the ability to …

Bioprinting is a method by which a cell-encapsulating bioink is patterned to create complex
tissue architectures. Given the potential impact of this technology on neural research, we …

Morphological and electrophysiological properties of neural cells are substantially
influenced by their immediate extracellular surroundings, yet the features of this environment …

Current understanding of human brain development is rudimentary due to suboptimal in
vitro and animal models. In particular, how initial cell positions impact subsequent human …

There is a high demand for in vitro models of the central nervous system (CNS) to study
neurological disorders, injuries, toxicity, and drug efficacy. Three-dimensional (3D) in vitro …