The efficacy of drugs against cancer in clinical settings may be limited due to
pharmacokinetic issues, side effects and the emergence of drug resistance. However, a …

Naphthalimide moiety is well known to possess various biological activities as it can very
well intercalate with DNA. In recent years, much of the attention has been given to the …

Pyrrolidine molecules are a significant class of synthetic and natural plant metabolites,
which show the diversity of pharmacological activities. An extensive variety of synthetic …

A series of amine substituted naphthalimide analogue were synthesized and evaluated for
in vitro anti-tumour activities against 60 tumour cell lines at a single dose concentration of 10 …

The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

New 1, 8-naphthalimido derivatives with 2, 3 and 4 carbon chains bearing a number of
different functionalities were synthesized and tested against a panel of breast cancer MCF-7 …

Based on the “2-phenylnaphthalene-type” structural pattern hypothesis developed in our
laboratory, a number of benzo [6] naphtho [2, 3-d] furan-6, ll-diones were designed …

Background: Naphthalimides have been receiving continuous attention for their outstanding
performance in treating cancer. However, as a class of cytotoxic anti-tumor agents, their toxic …

Ring-substituted hydroxynaphthanilides are considered as cyclic analogues of
salicylanilides, compounds possessing a wide range of pharmacological activities, including …

Our previous experimental work indicated that the presence of ester functionality in
phenanthrene derivatives D-1 and D-2 leads to potent cytotoxicity against the Caco-2 cell …