Thymoquinone attenuates diabetes-induced hepatic damage in rat via regulation of oxidative/nitrosative stress, apoptosis, and inflammatory cascade with molecular …

MH Hafez, SM Ez Elarab, HG Tohamy, AH El-Far - Scientific Reports, 2024 - nature.com
Diabetes mellitus (DM) is a complex metabolic condition that causes organ dysfunction. The
current experiment sought to determine the effect of thymoquinone (TQ) on hyperglycemia …

Thymoquinone, the most prominent constituent of Nigella sativa, attenuates liver damage in streptozotocin-induced diabetic rats via regulation of oxidative stress …

SA Almatroodi, AM Alnuqaydan, MA Alsahli, AA Khan… - Applied Sciences, 2021 - mdpi.com
Diabetes mellitus (DM) is a multifaceted metabolic disorder that results in dysfunction and
failure of various organs. The present study aimed to evaluate the role of Thymoquinone …

[HTML][HTML] Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt …

H Liu, HY Liu, YN Jiang, N Li - Molecular medicine …, 2016 - spandidos-publications.com
Thymoquinone is the main active monomer extracted from black cumin and has anti‑
inflammatory, antioxidant and anti‑apoptotic functions. However, the protective effects of …

Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats

C Sankaranarayanan, L Pari - Chemico-biological interactions, 2011 - Elsevier
The present study was aimed to investigate the effect of thymoquinone (TQ) on pancreatic
insulin levels, tissue antioxidant and lipid peroxidation (LPO) status in streptozotocin (STZ) …

Pharmacotherapy with thymoquinone improved pancreatic β-cell integrity and functional activity, enhanced islets revascularization, and alleviated metabolic and …

AG El-Shemi, OA Kensara, A Alsaegh, MH Mukhtar - Pharmacology, 2017 - karger.com
Aims: This study is aimed at evaluating the antidiabetic effects of thymoquinone (TQ) on
streptozotocin (STZ)-induced diabetes in rats, and exploring the possible underlying …

[PDF][PDF] Thymoquinone improves anti-diabetic activity of metformin in streptozotocin-induced diabetic male rats

B El-Aarag, W Hussein, W Ibrahim, M Zahran - J Diabetes Metab, 2017 - researchgate.net
The current study aimed to investigate the effects of thymoquinone (TQ) to enhance the anti-
diabetic effect of metformin (MET) in streptozotocin-induced diabetes in male rats. The …

Sakuranetin ameliorates streptozotocin-induced diabetes in rodents by inhibiting caspase-3 activity, modulating hematological parameters, and suppressing …

HH Almasoudi, MH Nahari, AS Binshaya… - Journal of …, 2024 - Taylor & Francis
Diabetes affects people of all ages, regardless of gender and background. To date, there is
no evidence for the effect of sakuranetin against the streptozotocin (STZ)-induced diabetes …

Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking …

SS Elblehi, MH Hafez, AH El-Far - Environmental Science and Pollution …, 2023 - Springer
Cypermethrin (CYP) is a synthetic pyrethroid utilized as an insecticide in agriculture and
various pest eradication programs. However, it induces numerous health hazards for …

Fangchinoline protects hepatic ischemia/reperfusion liver injury in rats through anti‐oxidative stress and anti‐inflammation properties: an in silico study

S Li, AD Xiang, F Guo, AA Alarfaj… - … and Applied Biochemistry, 2024 - Wiley Online Library
Liver ischemia‐reperfusion (I/R) injury is a common cause of organ failure, developed by a
sudden block in the blood and oxygen supply and subsequent restoration. I/R damage is …

[PDF][PDF] Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis

SR Galaly, OM Ahmed, AM Mahmoud - J Physiol Pharmacol, 2014 - jpp.krakow.pl
This study was conducted to assess the preventive effect of two plant constituents,
thymoquinone and curcumin, on gentamicin-induced deleterious effect on liver function …