Background Adult hematopoietic stem cells (HSCs) homeostasis is critically important in
maintaining lifelong hematopoiesis. However, how adult HSCs orchestrate its homeostasis …

Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy, exhibiting
a unique capacity to self-renew and differentiate into all blood cells throughout the lifetime …

Cancer stem cells (CSCs) are responsible for tumor initiation and progression. We
previously showed that Delta-like homolog 1 (DLK1) may be a therapeutic target against the …

Abstract The Delta-like (DLK1) gene is overexpressed in CD34+ cells from myelodysplastic
syndrome (MDS) patients. DLK1 encodes an EGF-like homeotic transmembrane protein …

Background Fully understanding the developmental process of hepatic stem cells (HSCs)
and the mechanisms of their committed differentiation is essential for optimizing the …

The first mouse adult-repopulating hematopoietic stem cells emerge in the aorta-gonad-
mesonephros region at embryonic day (E) 10.5. Their numbers in this region increase …

Abstract Ischemia-reperfusion (I/R) injury constitutes a significant risk factor for a range of
diseases, including ischemic stroke, myocardial infarction, and trauma. Following the …

The capacity to fine-tune cellular bioenergetics with the demands of stem-cell maintenance
and regeneration is central to normal development and ageing, and to organismal survival …

Disturbed mitochondrial dynamics are closely associated with the progression of different
types of cancer including hepatocellular carcinoma (HCC). However, the manner in which …

Durable humoral immunity against epidemic infectious disease requires the survival of long-
lived plasma cells (LLPCs). LLPC longevity is dependent on metabolic programs distinct …