The determination of tissue‐specific DNA methylation patterns in forensic biofluids using bisulfite modification and pyrosequencing

T Madi, K Balamurugan, R Bombardi… - …, 2012 - Wiley Online Library
The goal of this study is to explore the application of epigenetic markers in the identification
of biofluids that are commonly found at the crime scene. A series of genetic loci were …

Novel identification of biofluids using a multiplex methylation-specific PCR combined with single-base extension system

YC Lin, LC Tsai, JCI Lee, KL Liu, JTC Tzen… - … Science, Medicine, and …, 2016 - Springer
Purpose Knowledge of the composition of complex body fluid mixtures may aid forensic
investigations greatly. However, many of the traditional tests are presumptive in nature and …

Discovery of potential DNA methylation markers for forensic tissue identification using bisulphite pyrosequencing

A Vidaki, F Giangasparo… - Electrophoresis, 2016 - Wiley Online Library
The presence of specific body fluids at crime scenes could be linked with particular types of
crime, therefore attributing a DNA profile to a specific tissue could increase the evidential …

Developmental validation studies of epigenetic DNA methylation markers for the detection of blood, semen and saliva samples

DSBS Silva, J Antunes, K Balamurugan… - Forensic Science …, 2016 - Elsevier
Determining the type and origin of body fluids in a forensic investigation can provide
important assistance in reconstructing crime scenes. A set of epigenetic markers, ZC3H12D …

Novel identification of biofluids using a multiplex methylation sensitive restriction enzyme-PCR system

YC Lin, LC Tsai, JCI Lee, CW Su, JTC Tzen… - Forensic Science …, 2016 - Elsevier
The identification of a specific body fluid encountered in a forensic investigation can give
crucial information. This identification can be aided by methylation profiles based on …

Development of a body fluid identification multiplex via DNA methylation analysis

QT Gauthier, S Cho, JH Carmel, BR McCord - Electrophoresis, 2019 - Wiley Online Library
The goal of this study is to develop an epigenetic multiplex for body fluid identification based
on tissue specific DNA methylation. A series of genetic loci capable of discerning the origin …

Genome-wide methylation profiling and a multiplex construction for the identification of body fluids using epigenetic markers

HY Lee, JH An, SE Jung, YN Oh, EY Lee, A Choi… - Forensic Science …, 2015 - Elsevier
The identification of body fluids found at crime scenes can contribute to solving crimes by
providing important insights into crime scene reconstruction. In the present study, body fluid …

Identification of body fluid-specific DNA methylation markers for use in forensic science

JL Park, OH Kwon, JH Kim, HS Yoo, HC Lee… - Forensic Science …, 2014 - Elsevier
DNA methylation, which occurs at the 5′-position of the cytosine in CpG dinucleotides, has
great potential for forensic identification of body fluids, because tissue-specific patterns of …

Methylation markers for the identification of body fluids and tissues from forensic trace evidence

S Forat, B Huettel, R Reinhardt, R Fimmers, G Haidl… - PloS one, 2016 - journals.plos.org
The identification of body fluids is an essential tool for clarifying the course of events at a
criminal site. The analytical problem is the fact that the biological material has been very …

Potential forensic application of DNA methylation profiling to body fluid identification

HY Lee, MJ Park, A Choi, JH An, WI Yang… - International journal of …, 2012 - Springer
DNA analysis of various body fluid stains at crime scenes facilitates the identification of
individuals but does not currently determine the type and origin of the biological material …