Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine

JI Andorko, CM Jewell - Bioengineering & translational …, 2017 - Wiley Online Library
Recent research in the vaccine and immunotherapy fields has revealed that biomaterials
have the ability to activate immune pathways, even in the absence of other immune …

Tissue engineering tools for modulation of the immune response

RM Boehler, JG Graham, LD Shea - Biotechniques, 2011 - Taylor & Francis
Tissue engineering scaffolds have emerged as a powerful tool within regenerative medicine.
These materials are being designed to create environments that promote regeneration …

Biomaterial strategies for immunomodulation

NA Hotaling, L Tang, DJ Irvine… - Annual review of …, 2015 - annualreviews.org
Strategies to enhance, suppress, or qualitatively shape the immune response are of
importance for diverse biomedical applications, such as the development of new vaccines …

Biomimetic tissue engineering: tuning the immune and inflammatory response to implantable biomaterials

F Taraballi, M Sushnitha, C Tsao… - Advanced …, 2018 - Wiley Online Library
Regenerative medicine technologies rely heavily on the use of well‐designed biomaterials
for therapeutic applications. The success of implantable biomaterials hinges upon the ability …

Key players in the immune response to biomaterial scaffolds for regenerative medicine

L Chung, DR Maestas Jr, F Housseau… - Advanced drug delivery …, 2017 - Elsevier
The compatibility of biomaterials is critical to their structural and biological function in
medical applications. The immune system is the first responder to tissue trauma and to a …

T lymphocytes as critical mediators in tissue regeneration, fibrosis, and the foreign body response

KM Adusei, TB Ngo, K Sadtler - Acta Biomaterialia, 2021 - Elsevier
Research on the foreign body response (FBR) to biomaterial implants has been focused on
the roles that the innate immune system has on mediating tolerance or rejection of implants …

Tailoring materials for modulation of macrophage fate

J Li, X Jiang, H Li, M Gelinsky, Z Gu - Advanced Materials, 2021 - Wiley Online Library
Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

The role of biomaterials and scaffolds in immune responses in regenerative medicine: macrophage phenotype modulation by biomaterial properties and scaffold …

E Antmen, NE Vrana, V Hasirci - Biomaterials science, 2021 - pubs.rsc.org
Scaffolds are an integral part of the regenerative medicine field. The contact of biomaterials
with tissue, as was clearly observed over the years, induces immune reactions in a material …

Biomaterials-mediated engineering of the immune system

C Backlund, S Jalili-Firoozinezhad… - Annual review of …, 2023 - annualreviews.org
Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …

Divergent immune responses to synthetic and biological scaffolds

K Sadtler, MT Wolf, S Ganguly, CA Moad, L Chung… - Biomaterials, 2019 - Elsevier
The immune system plays a critical role in wound healing and the response to biomaterials.
Biomaterials-directed regenerative immunology is an immunoengineering strategy that …