Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability

TH Tran, Y Guo, D Song, RS Bruno, X Lu - Journal of pharmaceutical …, 2014 - Elsevier
Quercetin is a dietary flavonoid with potential chemoprotective effects, but has low
bioavailability because of poor aqueous solubility and low intestinal absorption. A quercetin …

Encapsulation and release of hydrophobic bioactive components in nanoemulsion-based delivery systems: Impact of physical form on quercetin bioaccessibility

H Pool, S Mendoza, H Xiao, DJ McClements - Food & function, 2013 - pubs.rsc.org
Many bioactive compounds are hydrophobic materials that are crystalline at ambient and
body temperatures, which reduces their bioavailability and poses challenges to their …

In vivo evaluation of a self-nanoemulsifying drug delivery system for curcumin

R Nazari-Vanani, L Moezi, H Heli - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Curcumin has attracted particular attention in recent years due to its great variety of
beneficial biological and pharmacological activities. However, its efficacy has been limited …

Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: implications for drug-induced cardiotoxicity and nephrotoxicity

S Jain, AK Jain, M Pohekar, K Thanki - Free Radical Biology and Medicine, 2013 - Elsevier
Quercetin (QT) was formulated into a novel self-emulsifying drug delivery system (SEDDS)
to improve its oral bioavailability and antioxidant potential compared to free drug. Capmul …

[HTML][HTML] Fabrication and evaluation of quercetin nanoemulsion: A delivery system with improved bioavailability and therapeutic efficacy in diabetes mellitus

M Mahadev, HS Nandini, R Ramu, DV Gowda… - Pharmaceuticals, 2022 - mdpi.com
The current study was intended to fabricate and evaluate ultrasonically assisted quercetin
nanoemulsion (Que-NE) for improved bioavailability and therapeutic effectiveness against …

Enhanced oral bioavailability and improved biological activities of a quercetin/resveratrol combination using a liquid self-microemulsifying drug delivery system

P Jaisamut, S Wanna, S Limsuwan, S Chusri… - Planta …, 2021 - thieme-connect.com
Both quercetin and resveratrol are promising plant-derived compounds with various well-
described biological activities; however, they are categorized as having low aqueous …

Preparation, characterization, and evaluation of antioxidant activity and bioavailability of a self-nanoemulsifying drug delivery system (SNEDDS) for buckwheat …

Z Zhao, X Cui, X Ma, Z Wang - Acta biochimica et biophysica …, 2020 - academic.oup.com
The self-nanoemulsifying drug delivery system has shown many advantages in drug
delivery. In this study, a self-nanoemulsifying drug delivery system of buckwheat flavonoids …

Design and optimization of self-nanoemulsifying delivery system to enhance quercetin hepatoprotective activity in paracetamol-induced hepatotoxicity

OAA Ahmed, SM Badr-Eldin, MK Tawfik… - Journal of …, 2014 - Elsevier
The present study aimed to develop optimized quercetin (QT)-loaded self-nanoemulsifying
drug delivery system (SNEDDS) that offers protective effect against liver damage. Solubility …

Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions

H Li, M Li, J Fu, H Ao, W Wang, X Wang - Drug Delivery, 2021 - Taylor & Francis
Abstract Quercetin-loaded nanosuspensions (Que-NSps) added metabolic inhibitors were
evaluated as drug delivery system to promote the oral bioavailability of quercetin. Que-NSps …

Oral delivery of quercetin in oil-in-water nanoemulsion: In vitro characterization and in vivo anti-obesity efficacy in mice

R Pangeni, SW Kang, M Oak, EY Park… - Journal of functional foods, 2017 - Elsevier
We sought to design an effective oral delivery system for quercetin (QCN) to enhance its
solubility and bioavailability and thus improve its anti-obesity effects. QCN-loaded oil-in …