Hippocampal metabolite profiles in two rat models of autism: NMR-based metabolomics studies

B Toczylowska, E Zieminska, P Senator… - Molecular …, 2020 - Springer
Autism spectrum disorders (ASDs) are increasingly being diagnosed. Hypotheses link ASD
to genetic, epigenetic, or environmental factors. The role of oxidative stress and the …

NMR-based metabolomics approach to explore brain metabolic changes induced by prenatal exposure to autism-inducing chemicals

AC Abreu, MM Navas, CP Fernández… - ACS Chemical …, 2021 - ACS Publications
NMR offers the unique potential to holistically screen hundreds of metabolites and has
already proved to be a powerful technique able to provide a global picture of a wide range of …

Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders

T Endo, T Shioiri, H Kitamura, T Kimura, S Endo… - Biological …, 2007 - Elsevier
BACKGROUND: Although several previous studies have been conducted, the neural basis
of autism spectrum disorder (ASD) is poorly understood. The objective of the present study …

Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study

L Margari, A De Giacomo, F Craig… - Neuropsychiatric …, 2018 - Taylor & Francis
Purpose Recently, neuroimaging studies were performed using 1H-magnetic resonance
spectroscopy (1H-MRS), revealing a quantitative alteration of neurochemicals (such as …

Metabolome signature of autism in the human prefrontal cortex

I Kurochkin, E Khrameeva, A Tkachev… - Communications …, 2019 - nature.com
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet
incompletely uncovered molecular determinants. Alterations in the abundance of low …

Untargeted metabolomic analysis reveals the metabolic disturbances and exacerbation of oxidative stress in the cerebral cortex of a BTBR mouse model of Autism

C Cao, Q Li, Y Chen, M Zou, C Sun, X Li… - Journal of Molecular …, 2023 - Springer
The etiology and pathology of autism spectrum disorders (ASDs) are still poorly understood,
which largely limit the treatment and diagnosis of ASDs. Emerging evidence supports that …

The lack of alterations in metabolites in the medial prefrontal cortex and amygdala, but their associations with autistic traits, empathy, and personality traits in adults …

Y Shirayama, K Matsumoto, F Osone, A Hara… - Journal of Autism and …, 2024 - Springer
Proton magnetic resonance spectroscopy (1H-MRS) has shown inconsistent alterations in
brain metabolites of adults with autism spectrum disorder (ASD). We investigated brain …

Metabolomics profiling of valproic acid-induced symptoms resembling autism spectrum disorders using 1H NMR spectral analysis in rat model

HY Kim, YJ Lee, SJ Kim, JD Lee, S Kim… - Journal of Toxicology …, 2022 - Taylor & Francis
Prenatal exposure to valproic acid (VPA) has been implicated in the manifestation of autism
spectrum disorder (ASD)-like behavioral and functional changes both in human and rodents …

Metabolomic signatures of autism spectrum disorder

D Brister, S Rose, L Delhey, M Tippett, Y Jin… - Journal of Personalized …, 2022 - mdpi.com
Autism Spectrum Disorder (ASD) is associated with many variations in metabolism, but the
ex-act correlates of these metabolic disturbances with behavior and development and their …

Age-related change in brain metabolite abnormalities in autism: a meta-analysis of proton magnetic resonance spectroscopy studies

Y Aoki, K Kasai, H Yamasue - Translational psychiatry, 2012 - nature.com
Abnormal trajectory of brain development has been suggested by previous structural
magnetic resonance imaging and head circumference findings in autism spectrum disorders …