Aging is associated with decreased bone mass and accumulation of bone marrow
adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived …

Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related
progressive disease characterized by reduced bone mass and increased risk of fractures. At …

Osteoblasts and adipocytes originate from a common progenitor, which arises from bone
marrow mesenchymal stroma/stem cells (mMSC). Aging causes a decrease in the number of …

The formation, maintenance, and repair of bone tissue involve close interlinks between two
stem cell types housed in the bone marrow: the hematologic stem cell originating …

In the adult bone marrow, osteoblasts and adipocytes share a common precursor called
mesenchymal stem cells (MSCs). The plasticity between the two lineages has been …

The aging population and the incidence of aging-related diseases such as osteoporosis are
on the rise. Aging at the tissue and organ levels usually involves tissue stem cells. Human …

Human bone marrow stroma contains pluripotent mesenchymal progenitor cells that can
give rise to many mesenchymal lineages, including chondroblasts, adipocytes or …

Because of their ability to self-renew and differentiate, mesenchymal stem cells (MSCs) are
the in vivo source for replacing lost cells in high-turnover tissues during the life of an …

Bone marrow (BM) microenvironment represents an important compartment of bone that
regulates bone homeostasis and the balance between bone formation and bone resorption …

Bone is a complex endocrine organ that facilitates structural support, protection to vital
organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow …