APOL1 kidney disease risk variants: an evolving landscape
PD Dummer, S Limou, AZ Rosenberg, J Heymann… - Seminars in …, 2015 - Elsevier
Summary Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of
chronic and end-stage kidney disease, which results in a significant global health disparity …
chronic and end-stage kidney disease, which results in a significant global health disparity …
APOL1 and Kidney Disease: From Genetics to Biology
DJ Friedman, MR Pollak - Annual review of physiology, 2020 - annualreviews.org
Genetic variants in the APOL1 gene, found only in individuals of recent African ancestry,
greatly increase risk of multiple types of kidney disease. These APOL1 kidney risk alleles …
greatly increase risk of multiple types of kidney disease. These APOL1 kidney risk alleles …
[HTML][HTML] APOL1 toxin, innate immunity, and kidney injury
The discovery that two common APOL1 alleles were strongly associated with nondiabetic
kidney diseases in African descent populations led to hope for improved diagnosis and …
kidney diseases in African descent populations led to hope for improved diagnosis and …
[HTML][HTML] The evolving story of apolipoprotein L1 nephropathy: the end of the beginning
P Daneshpajouhnejad, JB Kopp, CA Winkler… - Nature Reviews …, 2022 - nature.com
Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …
identified in 2010 and are relatively common among individuals of sub-Saharan African …
APOL1: the balance imposed by infection, selection, and kidney disease
P Beckerman, K Susztak - Trends in molecular medicine, 2018 - cell.com
Chronic kidney disease (CKD) affects millions of people and constitutes a major health and
financial burden worldwide. People of African descent are at an increased risk of developing …
financial burden worldwide. People of African descent are at an increased risk of developing …
Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity
Two coding variants in the apolipoprotein L1 (APOL1) gene (termed G1 and G2) are strongly
associated with increased risk of nondiabetic kidney disease in people of recent African …
associated with increased risk of nondiabetic kidney disease in people of recent African …
Intracellular APOL1 risk variants cause cytotoxicity accompanied by energy depletion
D Granado, D Müller, V Krausel… - Journal of the …, 2017 - journals.lww.com
Population genetic approaches have uncovered a strong association between kidney
diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and …
diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and …
APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases
OA Olabisi, JY Zhang, L VerPlank… - Proceedings of the …, 2016 - National Acad Sciences
Two specific genetic variants of the apolipoprotein L1 (APOL1) gene are responsible for the
high rate of kidney disease in people of recent African ancestry. Expression in cultured cells …
high rate of kidney disease in people of recent African ancestry. Expression in cultured cells …
Kidney disease-associated APOL1 variants have dose-dependent, dominant toxic gain-of-function
Background Two coding renal risk variants (RRVs) of the APOL1 gene (G1 and G2) are
associated with large increases in CKD rates among populations of recent African descent …
associated with large increases in CKD rates among populations of recent African descent …
Apolipoprotein L1 and kidney disease in African Americans
DJ Friedman, MR Pollak - Trends in Endocrinology & Metabolism, 2016 - cell.com
Genetic variants in the Apolipoprotein L1 (APOL1) gene cause high rates of kidney disease
in African Americans. These variants, found only in individuals with recent African ancestry …
in African Americans. These variants, found only in individuals with recent African ancestry …