[HTML][HTML] NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance

W Zhang, R Zhang, L Wu, C Zhu, C Zhang, C Xu… - Cell Reports, 2023 - cell.com
Oocyte maturation is vital to attain full competence required for fertilization and
embryogenesis. NLRP14 is preferentially expressed in mammalian oocytes and early …

Deletion of maternal UHRF1 severely reduces mouse oocyte quality and causes developmental defects in preimplantation embryos

Y Cao, M Li, F Liu, XB Ni, S Wang, H Zhang… - The FASEB …, 2019 - Wiley Online Library
The ubiquitin‐like, containing PHD and RING finger domains, 1 (UHRF1) protein recognizes
DNA methylation and histone modification and plays a critical role in epigenetic regulation …

NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte‐to‐Embryo Transition

TG Meng, JN Guo, L Zhu, Y Yin, F Wang… - Advanced …, 2023 - Wiley Online Library
Sperm‐induced Ca2+ rise is critical for driving oocyte activation and subsequent embryonic
development, but little is known about how lasting Ca2+ oscillations are regulated. Here it is …

[HTML][HTML] Maternal UHRF1 is essential for transcription landscapes and repression of repetitive elements during the maternal-to-zygotic transition

Y Wu, J Dong, S Feng, Q Zhao, P Duan… - Frontiers in Cell and …, 2021 - frontiersin.org
Maternal factors that modulate maternal-to-zygotic transition (MZT) are essential for the
growth from specialized oocytes to totipotent embryos. Despite several studies, the …

An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations

A Segarra-Fas, C Espejo-Serrano, F Bustos, H Zhou… - Science …, 2022 - science.org
The E3 ubiquitin ligase RNF12 plays essential roles during development, and the gene
encoding it, RLIM, is mutated in the X-linked human developmental disorder Tonne …

Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development

M Amoushahi, LL Steffensen, A Galieva… - Journal of Assisted …, 2020 - Springer
Purpose The aim of the study is to investigate presence and role of the gene encoding the
maternally contributed nucleotide-binding oligomerization domain (NOD)–like receptors with …

NLRP9B protein is dispensable for oocyte maturation and early embryonic development in the mouse

H Peng, X Lin, F Liu, C Wang… - Journal of Reproduction …, 2015 - jstage.jst.go.jp
Nlrp9a, Nlrp9b and Nlrp9c are preferentially expressed in oocytes and early embryos in the
mouse. Simultaneous genetic ablation of Nlrp9a and Nlrp9c does not affect early embryonic …

NLRP7 inter-domain interactions: the NACHT-associated domain is the physical mediator for oligomeric assembly

H Singer, A Biswas, N Zimmer… - MHR: Basic science …, 2014 - academic.oup.com
Mutations in NLRP7 (NOD-like-receptor family, pyrin domain containing 7) are responsible
for a type of recurrent pregnancy loss known as recurrent hydatidiform mole (HYDM1). This …

UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos

S Uemura, S Maenohara, K Inoue… - Life Science …, 2023 - life-science-alliance.org
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is a protein essential for the
maintenance of DNA methylation in somatic cells. However, UHRF1 is predominantly …

[HTML][HTML] NLRP7 is expressed in the ovine ovary and associated with in vitro pre-implantation embryo development

G Li, X Tian, D Lv, L Zhang, Z Zhang, J Wang… - …, 2019 - rep.bioscientifica.com
NLRP (NACHT, LRR and PYD domains-containing proteins) family plays the pivotal roles in
mammalian reproduction. Mutation of NLRP7 is often associated with human recurrent …