IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood
pressure and end-organ damage is unknown. We examined the role of IL-18 in the …

T cells participate in angiotensin II (Ang II)–induced hypertension. However, the specific
subsets of T cells that are important in the end-organ damage are unknown. T-helper 17 …

Interleukin (IL)-18 is a member of the IL-1 family of cytokines and was described originally as
an interferon γ-inducing factor. Aldosterone plays a central role in the regulation of sodium …

IL-18 function is neutralized in IL-18 binding protein transgenic (IL-18BP Tg) mice. First, we
determined whether IL-18BP Tg mice are protected against ischemic acute kidney injury …

Hypertension is now considered as an inflammatory disease, and the kidney is a key end-
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …

IL-18 is a proinflammatory cytokine produced by macrophages and other cell types present
in the kidney during ischemia-reperfusion injury (IRI), but its role in this injury is unknown …

IL-18 (formerly known as IFN-γ-inducing factor) enhances Th1 responses via effects that are
thought to be dependent on and synergistic with IL-12. The potential for IL-18 to exert IL-12 …

Background Interleukin 18 (IL-18) is a pro-inflammatory cytokine that mediates fibrotic renal
injury during obstruction. Macrophages are a well-known source of IL-18; however, renal …

IL-15, a T cell growth factor, has been linked to exacerbating autoimmune diseases and
allograft rejection. To test the hypothesis that IL-15–deficient (IL-15–/–) mice would be …

Abstract Interleukin (IL)-18 is a proinflammatory cytokine produced by leukocytes and
parenchymal cells (eg, tubular epithelial cells (TECs), mesangial cells, and podocytes). IL …