The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune
activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by …

The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …

Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases
associated with chronic activation of type I interferon (IFN) responses, including Aicardi …

We review the structures and functions of ADARs and their involvements in human diseases.
ADAR1 is widely expressed, particularly in the myeloid component of the blood system, and …

The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs.
Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi …

Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …

ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA
reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe …

Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …

ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate
adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects …

ADAR1 and ZBP1 are the only two mammalian proteins that contain Zα domains, which are
thought to bind to nucleic acids in the Z-conformation. These two molecules are crucial in …