Longitudinal analysis of the microbiome and metabolome in the 5xfAD mouse model of Alzheimer's disease

SJB Dunham, KA McNair, ED Adams… - MBio, 2022 - Am Soc Microbiol
Recent reports implicate gut microbiome dysbiosis in the onset and progression of
Alzheimer's disease (AD), yet studies involving model animals overwhelmingly omit the …

A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer's disease

F Favero, E Barberis, M Gagliardi, S Espinoza, L Contu… - Plos one, 2022 - journals.plos.org
The key role played by host-microbiota interactions on human health, disease onset and
progression, and on host response to treatments has increasingly emerged in the latest …

Gut microbiome and Mycobiome alterations in an in vivo model of Alzheimer's disease

V D'Argenio, I Veneruso, C Gong, V Cecarini, L Bonfili… - Genes, 2022 - mdpi.com
Gut microbiota has emerged as an important key regulator of health and disease status.
Indeed, gut microbial dysbiosis has been identified in an increasing number of diseases …

Predicting neurodegenerative disease using prepathology gut microbiota composition: a longitudinal study in mice modeling Alzheimer's disease pathologies

EM Borsom, K Conn, CR Keefe, C Herman… - Microbiology …, 2023 - Am Soc Microbiol
The gut microbiota-brain axis is suspected to contribute to the development of Alzheimer's
disease (AD), a neurodegenerative disease characterized by amyloid-β plaque deposition …

Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer's disease model mice

Y Chen, Y Li, Y Fan, S Chen, L Chen, Y Chen… - Gut …, 2024 - Taylor & Francis
The gut microbiota (GM) and its metabolites affect the host nervous system and are involved
in the pathogeneses of various neurological diseases. However, the specific GM alterations …

Gut microbiome alterations in Alzheimer's disease

NM Vogt, RL Kerby, KA Dill-McFarland, SJ Harding… - Scientific reports, 2017 - nature.com
Alzheimer's disease (AD) is the most common form of dementia. However, the
etiopathogenesis of this devastating disease is not fully understood. Recent studies in …

Exploring the microbiota-Alzheimer's disease linkage using short-term antibiotic treatment followed by fecal microbiota transplantation

M Wang, J Cao, C Gong, WK Amakye, M Yao… - Brain, Behavior, and …, 2021 - Elsevier
Gut microbiota is proven to be involved in the development of beta amyloid (Aβ) pathology in
Alzheimer's disease (AD). Since there are difficulties in translating microbiota findings based …

[HTML][HTML] Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in …

D Medina-Vera, EN Zambrana-Infantes… - Neurobiology of …, 2023 - Elsevier
The amyloid cascade hypothesis is widely accepted as an explanation for the
neuropathological changes in Alzheimer's disease (AD). However, the role of amyloid-beta …

Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer's disease

Z Li, H Zhu, Y Guo, X Du, C Qin - Journal of neurochemistry, 2020 - Wiley Online Library
Gut microbiota, comprising a vast number of microorganism species with complex
metagenome, are known to be associated with Alzheimer's disease (AD) and amyloid …

Alzheimer's disease and diabetes: Role of diet, microbiota and inflammation in preclinical models

MJ Carranza-Naval, M Vargas-Soria… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. Epidemiological studies
show the association between AD and type 2 diabetes (T2DM), although the mechanisms …