Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities

D Lozano, GS Gonzales-Portillo, S Acosta… - Neuropsychiatric …, 2015 - Taylor & Francis
Traumatic brain injury (TBI) is a serious public health problem accounting for 1.4 million
emergency room visits by US citizens each year. Although TBI has been traditionally …

Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention

A Kumar, DJ Loane - Brain, behavior, and immunity, 2012 - Elsevier
Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

[HTML][HTML] Neuroinflammation in traumatic brain injury: a chronic response to an acute injury

SJ Schimmel, S Acosta, D Lozano - Brain circulation, 2017 - journals.lww.com
Abstract Every year, approximately 1.4 million US citizens visit emergency rooms for
traumatic brain injuries. Formerly known as an acute injury, chronic neurodegenerative …

Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches

NK Prabhakar, H Khan, AK Grewal, TG Singh - International …, 2022 - Elsevier
TBI has been one of the top causes of death and morbidity worldwide, yet despite enormous
efforts to discover neuroprotective therapeutics for this serious disease, no beneficial …

Inflammation and neuroprotection in traumatic brain injury

KN Corps, TL Roth, DB McGavern - JAMA neurology, 2015 - jamanetwork.com
Importance Traumatic brain injury (TBI) is a significant public health concern that affects
individuals in all demographics. With increasing interest in the medical and public …

Neuroinflammation in animal models of traumatic brain injury

CC Chiu, YE Liao, LY Yang, JY Wang… - Journal of neuroscience …, 2016 - Elsevier
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide.
Neuroinflammation is prominent in the short and long-term consequences of neuronal …

Neuroinflammation and blood–brain barrier disruption following traumatic brain injury: pathophysiology and potential therapeutic targets

S Sulhan, KA Lyon, LA Shapiro… - Journal of neuroscience …, 2020 - Wiley Online Library
Abstract Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in
young adults and children in the developed world, occurring in over 1.7 million persons and …

Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities

Y Xiong, A Mahmood, M Chopp - Chinese Journal of Traumatology, 2018 - mednexus.org
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide.
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …

[HTML][HTML] Overview of traumatic brain injury: an immunological context

D Nizamutdinov, LA Shapiro - Brain sciences, 2017 - mdpi.com
Traumatic brain injury (TBI) afflicts people of all ages and genders, and the severity of injury
ranges from concussion/mild TBI to severe TBI. Across all spectrums, TBI has wide-ranging …

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …