Krüppel-like factor 4 (KLF4): What we currently know

AM Ghaleb, VW Yang - Gene, 2017 - Elsevier
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

Roles of Krüppel‐like factor 4 in normal homeostasis, cancer and stem cells

PM Evans, C Liu - Acta biochimica et biophysica Sinica, 2008 - Wiley Online Library
Krüppel‐like factor 4 (KLF4) is a zinc finger‐type transcription factor expressed in a variety of
tissues, including the epithelium of the intestine and the skin, and it plays an important role …

The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation

A Schuetz, D Nana, C Rose, G Zocher… - Cellular and Molecular …, 2011 - Springer
Abstract Krueppel-like factor 4 (Klf4) belongs to the Sp/Klf family of zinc-finger transcription
factors and is indispensable for terminal maturation of epithelial tissues. Furthermore, it is …

Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

AM Ghaleb, MO Nandan, S Chanchevalap, WB Dalton… - Cell research, 2005 - nature.com
Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription
factors with diverse regulatory functions in cell growth, proliferation, differentiation, and …

Klf10 and Klf11 as mediators of TGF-beta superfamily signaling

B Spittau, K Krieglstein - Cell and tissue research, 2012 - Springer
Klf10 and Klf11 belong to the family of Sp1/Krüppel-like zinc finger transcription factors that
play important roles in a variety of cell types and tissues. Although Klf10 and Klf11 were …

Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation

X Chen, EM Whitney, SY Gao, VW Yang - Journal of molecular biology, 2003 - Elsevier
Krüppel-like factor 4 (KLF4) is an epithelially enriched, zinc finger-containing transcription
factor, the expression of which is associated with growth arrest. Constitutive expression of …

Mammalian Krüppel-like factors in health and diseases

BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Two sides of the same coin: the roles of KLF6 in physiology and pathophysiology

SE Syafruddin, MA Mohtar, WF Wan Mohamad Nazarie… - Biomolecules, 2020 - mdpi.com
The Krüppel-like factors (KLFs) family of proteins control several key biological processes
that include proliferation, differentiation, metabolism, apoptosis and inflammation …

The roles and regulation of the KLF5 transcription factor in cancers

Y Luo, C Chen - Cancer science, 2021 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

Biology of Krüppel‐like factor 6 transcriptional regulator in cell life and death

V Andreoli, RC Gehrau, JL Bocco - IUBMB life, 2010 - Wiley Online Library
An essential role for the Krüppel-like transcription factor family has been determined in the
regulation of remarkable processes including cell proliferation, differentiation, signal …