Cryptococcus neoformans is an opportunistic fungal pathogen responsible for> 150,000
deaths every year with a mortality rate as high as 81%. This high medical burden is due, in …

ABSTRACT ATP-binding cassette (ABC) transporters represent one of the largest protein
superfamilies. Functionally diverse, ABC transporters have been implicated in many aspects …

Cryptococcus neoformans is a major etiological agent of fungal meningoencephalitis. The
outcome of cryptococcosis depends on the complex interactions between the pathogenic …

Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …

Many successful pathogens cause latent infections, remaining dormant within the host for
years but retaining the ability to reactivate to cause symptomatic disease. The human …

Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills almost
200,000 people worldwide each year. It is acquired when mammalian hosts inhale the …

Many aspects of the host response to invasive cryptococcal infections remain poorly
understood. In order to explore the pathobiology of infection with common clinical strains, we …

The substantial morbidity and mortality caused by invasive fungal pathogens, including
Cryptococcus neoformans, necessitates increased understanding of protective immune …

When transitioning from the environment, pathogenic microorganisms must adapt rapidly to
survive in hostile host conditions. This is especially true for environmental fungi that cause …

The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …