Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity
SL Gourley, A Olevska, MS Warren… - Journal of …, 2012 - Soc Neuroscience
Adolescence is characterized by vulnerability to the development of neuropsychiatric
disorders including drug addiction, as well as prefrontal cortical refinement that culminates …
disorders including drug addiction, as well as prefrontal cortical refinement that culminates …
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
SL Gourley, AJ Koleske… - Proceedings of the …, 2009 - National Acad Sciences
Adolescence is characterized by increased vulnerability to developing neuropsychiatric
disorders and involves a period of prefrontal cortical dendritic refinement and synaptic …
disorders and involves a period of prefrontal cortical dendritic refinement and synaptic …
The dendritic spine morphogenic effects of repeated cocaine use occur through the regulation of serum response factor signaling
The nucleus accumbens (NAc) is a primary brain reward region composed predominantly of
medium spiny neurons (MSNs). In response to early withdrawal from repeated cocaine …
medium spiny neurons (MSNs). In response to early withdrawal from repeated cocaine …
Induction and blockade of adolescent cocaine-induced habits
Background Cocaine use during adolescence increases vulnerability to drug dependence
and decreases the likelihood that individuals will seek treatment as adults. Understanding …
and decreases the likelihood that individuals will seek treatment as adults. Understanding …
Synaptic cytoskeletal plasticity in the prefrontal cortex following psychostimulant exposure
LM DePoy, SL Gourley - Traffic, 2015 - Wiley Online Library
Addiction is characterized by maladaptive decision‐making, a loss of control over drug
consumption and habit‐like drug seeking despite adverse consequences. These cognitive …
consumption and habit‐like drug seeking despite adverse consequences. These cognitive …
[HTML][HTML] Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors
Cocaine and amphetamine remodel dendritic spines within discrete cortico-limbic brain
structures including the orbitofrontal cortex (oPFC). Whether dendrite structure is similarly …
structures including the orbitofrontal cortex (oPFC). Whether dendrite structure is similarly …
Synaptic microtubule-associated protein EB3 and SRC phosphorylation mediate structural and behavioral adaptations during withdrawal from cocaine self …
Addictive behaviors, including relapse, are thought to depend in part on long-lasting drug-
induced adaptations in dendritic spine signaling and morphology in the nucleus accumbens …
induced adaptations in dendritic spine signaling and morphology in the nucleus accumbens …
Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: implications for cortical development
LP Shapiro, RG Parsons, AJ Koleske… - Journal of …, 2017 - Wiley Online Library
The prevalence of depression, anxiety, schizophrenia, and drug and alcohol use disorders
peaks during adolescence. Further, up to 50% of “adult” mental health disorders emerge in …
peaks during adolescence. Further, up to 50% of “adult” mental health disorders emerge in …
Signaling via dopamine D1 and D3 receptors oppositely regulates cocaine-induced structural remodeling of dendrites and spines
Repeated exposure to cocaine can induce persistent alterations in the brain. The structural
remodeling of dendrites and dendritic spines is thought to play a critical role in cocaine …
remodeling of dendrites and dendritic spines is thought to play a critical role in cocaine …
Withdrawal from repeated morphine administration augments expression of the RhoA network in the nucleus accumbens to control synaptic structure
The nucleus accumbens (NA c) is a critical brain reward region that mediates the rewarding
effects of drugs of abuse, including those of morphine and other opiates. Drugs of abuse …
effects of drugs of abuse, including those of morphine and other opiates. Drugs of abuse …