Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and …

JX Li, RZ Li, A Sun, H Zhou, E Neher, JS Yang… - Pharmacological …, 2021 - Elsevier
Currently, conventional methods of treating non-small cell lung cancer (NSCLC) have many
disadvantages. An alternative effective therapy with minimal adverse reactions is urgently …

[HTML][HTML] Network analysis and mechanisms of action of Chinese herb-related natural compounds in lung cancer cells

YJ Lin, WM Liang, CJ Chen, H Tsang, JS Chiou, X Liu… - Phytomedicine, 2019 - Elsevier
Abstract Background Chinese herbal medicines (CHMs) are a resource of natural
compounds (ingredients) and their potential chemical derivatives with anticancer properties …

A Mixture of Baicalein, Wogonin, and Oroxylin-A Inhibits EMT in the A549 Cell Line via the PI3K/AKT-TWIST1-Glycolysis Pathway

HJ Cao, W Zhou, XL Xian, SJ Sun, PJ Ding… - Frontiers in …, 2022 - frontiersin.org
Non-small cell lung cancer (NSCLC) is a worldwide disease with a high morbidity and
mortality rate, which is most derived from its metastasis. Some studies show that the …

[HTML][HTML] Effect and mechanism of Banxia Xiexin decoction in colorectal cancer: a network pharmacology approach

Y Wang, T Zhao, C Huang, F Liu, Y Zhang, D Kong… - Phytomedicine, 2024 - Elsevier
Abstract Background Banxia Xiexin decoction (BXD) is a traditional Chinese medicine with
anti-colorectal cancer (CRC) activity. However, its bioactive constituents and its mechanism …

A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong …

F Lin, G Zhang, X Yang, M Wang, R Wang… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Wei-Tong-Xin (WTX), derives from the Chinese
herbal decoction (CHD) of Wan-Ying-Yuan in ancient China, has been shown to be effective …

Network pharmacology based research into the effect and mechanism of Yinchenhao Decoction against Cholangiocarcinoma

Z Chen, T Lin, X Liao, Z Li, R Lin, X Qi, G Chen, L Sun… - Chinese medicine, 2021 - Springer
Background Cholangiocarcinoma refers to an epithelial cell malignancy with poor
prognosis. Yinchenhao decoction (YCHD) showed positive effects on cancers, and …

Systems biology strategy and experimental validation to uncover the pharmacological mechanism of Xihuang Pill in treating non-small cell lung cancer

Z Zhuang, D Huang, ZR Sheng, ZJ Ye, H Jiang, Y Yuan… - Phytomedicine, 2023 - Elsevier
Background Non-small cell lung cancer (NSCLC) accounts for almost 85% of lung cancer-
related deaths worldwide. Xihuang Pill (XHP) is a representative anticancer Chinese …

Exploration of the Potential Mechanism of Tao Hong Si Wu Decoction for the Treatment of Breast Cancer Based on Network Pharmacology and In Vitro Experimental …

S Huang, Y Chen, L Pan, C Fei, N Wang, F Chu… - Frontiers in …, 2021 - frontiersin.org
Background Tao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese
medicine used clinically alone or combined with drugs to treat breast cancer. However, there …

[HTML][HTML] Modulatory effects of Xihuang Pill on lung cancer treatment by an integrative approach

C Li, W Chen, M Zhang, C Zhang, B Cao… - Biomedicine & …, 2020 - Elsevier
Lung cancer has a rapidly increasing incidence and remains the highest ranked cancer in
terms of mortality worldwide. Xihuang Pill (XHW), a famous four-herb traditional Chinese …

[HTML][HTML] Optimizing component formula suppresses lung cancer by blocking DTL-mediated PDCD4 ubiquitination to regulate the MAPK/JNK pathway

Q Fan, Q Lu, G Wang, W Zhu, L Teng, W Chen… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Salvia miltiorrhiza Bunge and Panax ginseng CA
Meyer have special curative effect on cancer treatment. The optimizing component formula …