RNA splicing represents a post-transcriptional mechanism to generate multiple functional
RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example …

Alternative splicing is an important mechanism used by the cell to generate greater
transcriptomic and proteomic diversity from the genome. In the heart, alternative splicing is …

Despite advances in therapeutics for heart failure and arrhythmias, a substantial proportion
of patients with cardiomyopathy do not respond to interventions, indicating a need to identify …

Alternative splicing generates specialized protein isoforms that allow the heart to adapt
during development and disease. The recent discovery that mutations in the splicing factor …

Alternative splicing, a driver of posttranscriptional variance, differs from canonical splicing by
arranging the introns and exons of an immature pre-mRNA transcript in a multitude of …

Alternative splicing is the main driver of protein diversity and allows the production of
different proteins from each gene in the genome. Changes in exon exclusion, intron …

Background—Alternative mRNA splicing is an important mechanism for regulation of gene
expression. Altered mRNA splicing occurs in association with several types of cancer, and a …

Pre-mRNA splicing is an important biological process that allows production of multiple
proteins from a single gene in the genome, and mainly contributes to protein diversity in …

Alternative splicing (AS) plays an important role in regulating mammalian heart
development, but a link between misregulated splicing and congenital heart defects (CHDs) …

Driven by rapidly evolving technologies in next-generation sequencing, alternative splicing
has emerged as a crucial layer in gene expression, greatly expanding protein diversity and …