The evolution of novel traits can involve many mutations scattered throughout the genome,.
Detecting and validating such a suite of alleles, particularly if they arose long ago, remains a …

How gene duplication and divergence contribute to genetic novelty and adaptation has
been of intense interest, but experimental evidence has been limited. The genetic switch …

Local adaptations within species are often governed by several interacting genes scattered
throughout the genome. Single-locus models of selection cannot explain the maintenance of …

Metabolic pathways differ across species but are expected to be similar within a species. We
discovered two functional, incompatible versions of the galactose pathway in …

When Saccharomyces cerevisiae grows on mixtures of glucose and galactose, galactose
utilization is repressed by glucose, and induction of the GAL gene network only occurs when …

Understanding the genetic basis of evolutionary adaptation is limited by our ability to
efficiently identify the genomic locations of adaptive mutations. Here we describe a method …

Identifying the mechanisms of eukaryotic genome evolution by comparative genomics is
often complicated by the multiplicity of events that have taken place throughout the history of …

Determining the effect of gene deletion is a fundamental approach to understanding gene
function. Conventional genetic screens exhibit biases, and genes contributing to a …

A whole-genome duplication occurred in a shared ancestor of the yeast species
Saccharomyces cerevisiae, Saccharomyces castellii and Candida glabrata. Here we trace …

The dynamics of adaptation determine which mutations fix in a population, and hence how
reproducible evolution will be. This is central to understanding the spectra of mutations …