Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …

Plasma HDL-cholesterol concentrations correlate negatively with the risk of atherosclerotic
cardiovascular disease (ASCVD). According to a widely cited model, HDL elicits its …

The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating …

Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the
formation of the atherosclerotic plaque, characterized by the accumulation of abnormal …

Our understanding of the in-vivo metabolism of HDL particles and their role in reverse
cholesterol transport is rapidly evolving, with long-standing concepts being constantly …

Low high-density lipoprotein cholesterol (HDL-C) levels are associated with incident
cardiovascular events; however, many therapies targeting increases in HDL-C have failed to …

Despite a robust inverse association between high-density lipoprotein (HDL) cholesterol
levels and atherosclerotic cardiovascular disease, the development of new therapies based …

Atherosclerosis is characterized by lipid accumulation, inflammatory response, cell death
and fibrosis in the arterial wall, and is a major pathological basis for ischemic coronary heart …

Since the pioneering work of John Gofman in the 1950s, our understanding of high density
lipoprotein cholesterol (HDL-C) and its relationship to coronary heart disease (CHD) has …

High-density lipoproteins (HDLs) are among the most structurally complex and functionally
versatile forms of circulating serum lipoproteins. HDLs undergo extensive enzymatic …