Mechanisms of action of glucagon-like peptide 1 in the pancreas

ME Doyle, JM Egan - Pharmacology & therapeutics, 2007 - Elsevier
Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

The structure and function of the glucagon‐like peptide‐1 receptor and its ligands

D Donnelly - British journal of pharmacology, 2012 - Wiley Online Library
Glucagon‐like peptide‐1 (7‐36) amide (GLP‐1) is a 30‐residue peptide hormone released
from intestinal L cells following nutrient consumption. It potentiates the glucose‐induced …

Glucagon-like peptide-1: a major regulator of pancreatic beta-cell function

R Perfetti, P Merkel - European Journal of Endocrinology, 2000 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) is a gut hormone synthesized by post-translational
processing in intestinal L-cells, and it is released in response to food ingestion. GLP-1 …

Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus

DD De León, MF Crutchlow, JYN Ham… - The international journal …, 2006 - Elsevier
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L
cells in response to ingested nutrients. The first recognized and most important action of …

Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain

S Runge, S Schimmer, J Oschmann, CB Schiødt… - Biochemistry, 2007 - ACS Publications
Glucagon-like peptide-1 (GLP-1) and exendin-4 (Ex4) are homologous peptides with
established potential for treatment of type 2 diabetes. They bind and activate the pancreatic …

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion

PE MacDonald, W El-Kholy, MJ Riedel… - Diabetes, 2002 - Am Diabetes Assoc
The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense interest
because of the potential clinical relevance of this peptide. Produced in intestinal L-cells …

Glucagon and glucagon-like peptide receptors as drug targets

JL Estall, DJ Drucker - Current pharmaceutical design, 2006 - ingentaconnect.com
Glucagon and the glucagon-like peptides are derived from a common proglucagon
precursor, and regulate energy homeostasis through interaction with a family of distinct G …

Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1

J Gromada, JJ Holst, P Rorsman - Pflügers Archiv, 1998 - Springer
Glucagon-like peptide 1 is a gastrointestinally derived hormone with profound effects on
nutrient-induced pancreatic hormone release. GLP-1 modulates insulin, glucagon and …

Effect of GLP-1 on glucose transport and its cell signalling in human myocytes

N González, A Acitores, V Sancho, I Valverde… - Regulatory peptides, 2005 - Elsevier
Glucagon-like peptide-1 (GLP-1) controls glucose metabolism in extrapancreatic tissues
participating in glucose homeostasis, through receptors not associated to cAMP. In rat …

Glucagon-like peptide 1 (GLP-1): an intestinal hormone, signalling nutritional abundance, with an unusual therapeutic potential

JJ Holst - Trends in Endocrinology & Metabolism, 1999 - cell.com
The incretin hormone, glucagon-like peptide 1 (GLP-1) has many actions; namely:(1) it
enhances all steps of insulin biosynthesis and potentiates glucose-induced secretion;(2) it …