[HTML][HTML] Ubiquitination, biotech startups, and the future of TRIM family proteins: a TRIM-Endous opportunity
U Bhaduri, G Merla - Cells, 2021 - mdpi.com
Ubiquitination is a post-translational modification that has pivotal roles in protein
degradation and diversified cellular processes, and for more than two decades it has been a …
degradation and diversified cellular processes, and for more than two decades it has been a …
[HTML][HTML] Cellular function of TRIM E3 ubiquitin ligases in health and disease
G Meroni, S Desagher - Cells, 2022 - mdpi.com
The field of the Tripartite Motif (TRIM) family has progressively attracted increasing interest
during the last two decades. The presence of a distinctive amino-terminal module …
during the last two decades. The presence of a distinctive amino-terminal module …
TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation
LM Napolitano, G Meroni - IUBMB life, 2012 - Wiley Online Library
The TRIM family is composed of multidomain ubiquitin E3 ligases characterized by the
presence of the N‐terminal tripartite motif (RING, B‐boxes, and coiled coil). TRIM proteins …
presence of the N‐terminal tripartite motif (RING, B‐boxes, and coiled coil). TRIM proteins …
TRIM proteins and diseases
M Watanabe, S Hatakeyama - The Journal of Biochemistry, 2017 - academic.oup.com
Ubiquitination is one of the posttranslational modifications that regulates a number of
intracellular events including signal transduction, protein quality control, transcription, cell …
intracellular events including signal transduction, protein quality control, transcription, cell …
[HTML][HTML] Structural insights into the TRIM family of ubiquitin E3 ligases
TRIM proteins play important roles in a wide range of biological processes, including cell
proliferation, differentiation, development, apoptosis, oncogenesis and innate immunity [1 …
proliferation, differentiation, development, apoptosis, oncogenesis and innate immunity [1 …
Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases
The tripartite motif (TRIM) gene family is a highly conserved group of E3 ubiquitin ligase
proteins that can establish substrate specificity for the ubiquitin-proteasome complex and …
proteins that can establish substrate specificity for the ubiquitin-proteasome complex and …
[HTML][HTML] The roles and targeting options of TRIM family proteins in tumor
Y Zhang, W Zhang, L Zheng, Q Guo - Frontiers in Pharmacology, 2022 - frontiersin.org
Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are
critically implicated in the occurrence and development of tumors. They can function through …
critically implicated in the occurrence and development of tumors. They can function through …
TRIM family proteins: roles in autophagy, immunity, and carcinogenesis
S Hatakeyama - Trends in biochemical sciences, 2017 - cell.com
Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have
various functions in cellular processes including intracellular signaling, development …
various functions in cellular processes including intracellular signaling, development …
Structural determinants of TRIM protein function
D Esposito, MG Koliopoulos… - Biochemical Society …, 2017 - portlandpress.com
Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of Really Interesting
New Gene (RING) E3 ubiquitin ligases and contribute to the regulation of numerous cellular …
New Gene (RING) E3 ubiquitin ligases and contribute to the regulation of numerous cellular …
[HTML][HTML] E3 ubiquitin ligase TRIM proteins, cell cycle and mitosis
S Venuto, G Merla - Cells, 2019 - mdpi.com
The cell cycle is a series of events by which cellular components are accurately segregated
into daughter cells, principally controlled by the oscillating activities of cyclin-dependent …
into daughter cells, principally controlled by the oscillating activities of cyclin-dependent …