Colchicine (COL) has been used in medicine for a long time. It is well recognized as a valid
therapy in acute flares of gouty arthritis, familial Mediterranean fever (FMF), Behçet's …

Objectives To review the literature and provide an update on the mechanisms of action and
therapeutic uses of oral colchicine in arthritis and inflammatory conditions. Methods We …

OBJECTIVE:: To present an update of the use of colchicine in patients with familial
Mediterranean fever (FMF) and other rheumatic and nonrheumatic diseases. DATA …

Although colchicine has been a focus of research, debate, and controversy for thousands of
years, the US Food and Drug Administration just approved it in 2009. Over the past decade …

OBJECTIVES: To review recent advances in the understanding of molecular mechanisms of
drug disposition and cellular mechanisms of action and targets of colchicine, and disease …

Colchicine is used chiefly in the treatment of gout but is also valuable in other inflammatory
diseases such as familial Mediterranean fever (FMF). Three proteins play pivotal roles in …

Introduction: Colchicine has been successfully used for the treatment of neutrophilic
disorders such as familial Mediterranean fever (FMF), Behçet disease (BD) and gout. There …

Colchicine is an ancient drug that is attracting renewed interest because of its actions at a
subcellular level. Specifically, it interferes with microtubule growth and therefore affects …

Although colchicine, a natural product, is one of the oldest drugs still currently available, its
possible functions seem to be surprisingly not well-known. Beyond its present medicinal use …

Colchicine has been traditionally used for the treatment of gout. At present there is no
generally accepted alternative to colchicine for the treatment of acute attacks or for the …